25-hydroxycholecalciferol in the management of rickets associated with extrahepatic biliary atresia

Fredric Daum, John F. Rosen, Martin Roginsky, Michael I. Cohen, Laurence Finberg

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


In children with extrahepatic biliary atresia, impaired hydroxylation and defective intestinal absorption of cholecalciferol may lead to a deficiency of vitamin D and rickets. The data presented herein demonstrate that in such patients serum levels of vitamin D measured as 25-hydroxycalciferol are reduced. A moderate therapeutic oral dose of 25-hydroxycholecalciferol, by circumventing the hepatic conversion of cholecalciferol to 25-hydroxycholecalciferol, will replete vitamin D stores and maintain the serum concentration of 25-hydroxycalciferol required to prevent or heal rickets in these patients.

Original languageEnglish (US)
Pages (from-to)1041-1043
Number of pages3
JournalThe Journal of Pediatrics
Issue number6
StatePublished - Jun 1976

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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