Δ9-Tetrahydroeannabinol enhances presynaptic dopamine efflux In medial prefrontal cortex

Chen Jianping; William Paredes; Joyce H. Lowinson; Eliot L. Gardner

doi:10.1016/0014-2999(90)94136-L

Δ⁹-Tetrahydroeannabinol enhances presynaptic dopamine efflux In medial prefrontal cortex

Chen Jianping, William Paredes, Joyce H. Lowinson, Eliot L. Gardner

Medicine

Research output: Contribution to journal › Article › peer-review

123 Scopus citations

Abstract

Acute administration of 1.0-2.0 mg/kg Δ⁹-tetrahydrocannabinoI Δ⁹-THC) increased presynaptic dopamine (DA) efflux in the medial prefrontal cortex of rats, as measured by intracerebral microdialysis in awake, behaving rats. These data are congruent with suggestions that (1) marijuana's euphorigenic effects and abuse potential may be related to augmentation of presynaptic DA mechanisms, and (2) the medial prefrontal cortex may be an important site of action for drugs of abuse in general and for Δ⁹-THC in particular.

Original language	English (US)
Pages (from-to)	259-262
Number of pages	4
Journal	European Journal of Pharmacology
Volume	190
Issue number	1-2
DOIs	https://doi.org/10.1016/0014-2999(90)94136-L
State	Published - Nov 6 1990

Keywords

Cortex (medial prefrontal)
Dopamine
Drugs of abuse
Marijuana
Microdialysis
Δ-Tetrahydrocannabinol

ASJC Scopus subject areas

Pharmacology

Access to Document

10.1016/0014-2999(90)94136-L

Cite this

@article{915f3f2c935d4c519cb74134e6ab5a96,

title = "Δ9-Tetrahydroeannabinol enhances presynaptic dopamine efflux In medial prefrontal cortex",

abstract = "Acute administration of 1.0-2.0 mg/kg Δ9-tetrahydrocannabinoI Δ9-THC) increased presynaptic dopamine (DA) efflux in the medial prefrontal cortex of rats, as measured by intracerebral microdialysis in awake, behaving rats. These data are congruent with suggestions that (1) marijuana's euphorigenic effects and abuse potential may be related to augmentation of presynaptic DA mechanisms, and (2) the medial prefrontal cortex may be an important site of action for drugs of abuse in general and for Δ9-THC in particular.",

keywords = "Cortex (medial prefrontal), Dopamine, Drugs of abuse, Marijuana, Microdialysis, Δ-Tetrahydrocannabinol",

author = "Chen Jianping and William Paredes and Lowinson, {Joyce H.} and Gardner, {Eliot L.}",

note = "Funding Information: This study was partially supportedb y NIDA Grant DA03622,N IH Grant RR05397,N SF Grant BNS-8609351 and the New York State Departmento f SubstanceA buse ServicesW. e areg ratefutl o Jin Li for technicaal ssistancea,n d to HermanM . van Praag,M .D., Ph.D., Chairman,D epartment of Psychiatry,A lbert Einstein Collegeo f Medicine,f or support.",

year = "1990",

month = nov,

day = "6",

doi = "10.1016/0014-2999(90)94136-L",

language = "English (US)",

volume = "190",

pages = "259--262",

journal = "European Journal of Pharmacology",

issn = "0014-2999",

publisher = "Elsevier",

number = "1-2",

}

TY - JOUR

T1 - Δ9-Tetrahydroeannabinol enhances presynaptic dopamine efflux In medial prefrontal cortex

AU - Jianping, Chen

AU - Paredes, William

AU - Lowinson, Joyce H.

AU - Gardner, Eliot L.

N1 - Funding Information: This study was partially supportedb y NIDA Grant DA03622,N IH Grant RR05397,N SF Grant BNS-8609351 and the New York State Departmento f SubstanceA buse ServicesW. e areg ratefutl o Jin Li for technicaal ssistancea,n d to HermanM . van Praag,M .D., Ph.D., Chairman,D epartment of Psychiatry,A lbert Einstein Collegeo f Medicine,f or support.

PY - 1990/11/6

Y1 - 1990/11/6

N2 - Acute administration of 1.0-2.0 mg/kg Δ9-tetrahydrocannabinoI Δ9-THC) increased presynaptic dopamine (DA) efflux in the medial prefrontal cortex of rats, as measured by intracerebral microdialysis in awake, behaving rats. These data are congruent with suggestions that (1) marijuana's euphorigenic effects and abuse potential may be related to augmentation of presynaptic DA mechanisms, and (2) the medial prefrontal cortex may be an important site of action for drugs of abuse in general and for Δ9-THC in particular.

AB - Acute administration of 1.0-2.0 mg/kg Δ9-tetrahydrocannabinoI Δ9-THC) increased presynaptic dopamine (DA) efflux in the medial prefrontal cortex of rats, as measured by intracerebral microdialysis in awake, behaving rats. These data are congruent with suggestions that (1) marijuana's euphorigenic effects and abuse potential may be related to augmentation of presynaptic DA mechanisms, and (2) the medial prefrontal cortex may be an important site of action for drugs of abuse in general and for Δ9-THC in particular.

KW - Cortex (medial prefrontal)

KW - Dopamine

KW - Drugs of abuse

KW - Marijuana

KW - Microdialysis

KW - Δ-Tetrahydrocannabinol

UR - http://www.scopus.com/inward/record.url?scp=0025066598&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025066598&partnerID=8YFLogxK

U2 - 10.1016/0014-2999(90)94136-L

DO - 10.1016/0014-2999(90)94136-L

M3 - Article

C2 - 1963849

AN - SCOPUS:0025066598

SN - 0014-2999

VL - 190

SP - 259

EP - 262

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 1-2

ER -