The role of NF-kappaB signaling in breast cancer metastasis

Project Narrative Approximately 1500 people die each day in the United States from cancer, and cancer metastasis from the original or primary tumor is responsible for more than 90% of these cancer deaths. Identification of the molecular basis of tumor metastasis is fundamental to development of improved anti-metastatic therapies to increase patient survival. This study aims to investigate the mechanisms that control or promote tumor cell metastasis in the hope that in the long term we can develop new strategies to target these signals and prevent cancer metastasis and patient death.