Multi-omics approach to frailty resilience

Project Narrative Frailty is a common clinical condition in older adults that is characterized by increased vulnerability to disability and mortality, and is a major burden for the healthcare system in the United States. Aging is the main risk factor for frailty; however, families of centenarians delay aging and are protected from frailty. Identifying genes and biological markers that protect from the effects of aging is an important step in the development of effective therapies that protect from and delay frailty.