Genetic variant-based drug discovery targeting conserved pathways of aging

Search results

• Active

  Validation and characterization of the identified variants associated with human longevity in mouse models

  Vijg, J.

  National Institute on Aging

  8/1/23 → 7/31/24

  Project: Research project

  • Longevity 100%
  • NF-kappa B 49%
  • Haploinsufficiency 39%
  • Aged, 80 and over 37%
  • 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one 28%

• Identification and characterization of functional genetic variants associated with human longevity

  Vijg, J.

  National Institute on Aging

  8/1/23 → 7/31/24

  Project: Research project

  • Longevity 100%
  • Psychological Identification 88%
  • Healthy Aging 43%
  • Alzheimer Disease 26%
  • High-Throughput Screening Assays 24%

• Genetics of extreme human longevity

  Zhang, Z.

  National Institute on Aging

  8/1/23 → 7/31/24

  Project: Research project

  • Aged, 80 and over 100%
  • Longevity 80%
  • Single Molecule Imaging 22%
  • Genome 22%
  • Exome 19%

• Development of novel therapeutics targeting the identified pathways associated with human longevity

  Vijg, J.

  National Institute on Aging

  8/1/23 → 7/31/24

  Project: Research project

  • Aged, 80 and over 100%
  • NF-kappa B 87%
  • fucoidan 60%
  • Longevity 55%
  • DNA Repair 37%

• Administrative Core

  Vijg, J.

  National Institute on Aging

  8/1/23 → 7/31/24

  Project: Research project

  • Aged, 80 and over 100%
  • Medicine 59%
  • Pharmaceutical Preparations 50%
  • Exome 49%
  • Preclinical Drug Evaluations 48%

• Data Integration and Sharing Core

  Zhang, Z.

  National Institute on Aging

  8/1/23 → 7/31/24

  Project: Research project

  • Data integration 100%
  • Data Sharing 99%
  • Genomics 41%
  • Prodrugs 38%
  • Ports and harbors 23%