Physiology & Biophysics

Projects

Projects per year 1976 1992 1995 1997 2000 2002 2004 2006 2010 2012 2017 2022

• 1 Active
• 81 Finished

Projects per year

Search results

• Finished

  Maximizing transfusion efficacy through nitric oxide enhancement strategies

  Friedman, J. M.

  9/20/19 → 8/31/21

  Project: Research project

  • blood transfusion 100%
  • nitric oxide 69%
  • anemia 38%
  • blood viscosity 30%
  • blood flow 27%

• Development of a nanotechnology resource center to advance urological research

  Davies, K. & Friedman, J. M.

  9/17/19 → 6/30/21

  Project: Research project

  • Nanoparticles 100%
  • Nanotechnology 89%
  • Research Personnel 26%
  • Urologic Diseases 17%
  • Resource Allocation 14%

• A Novel Therapeutic that Harnesses Microtubules to Promote Cavernous Nerve Regeneration after Radical Prostatectomy

  Sharp, D. J.

  9/20/18 → 8/31/19

  Project: Research project

  • Prostatectomy 100%
  • Erectile Dysfunction 81%
  • Small Interfering RNA 63%
  • Prostatic Neoplasms 25%
  • Microtubules 21%

• Capture and characterize transient catalytic intermediates by X-ray crystallography

  Rousseau, D. L.

  2/1/18 → 1/31/21

  Project: Research project

  • Holder 100%
  • X-Ray Crystallography 84%
  • Cytochrome 53%
  • Oxidase Reaction 30%
  • Time 29%

• Structures of time-resolved intermediates in cytochrome c oxidase obtained by serial femtosecond crystallography

  Rousseau, D. L., Yeh, S. & Yeh, S.

  9/15/17 → 8/31/21

  Project: Research project

  • Cytochrome 100%
  • Proton 53%
  • Carbon Monoxide 42%
  • X-Ray Crystallography 27%
  • Crystal Structure 24%

• Development of a Topical siRNA Therapy to Promote Burn Wound Healing via Depletion of the Novel Microtubule Regulatory, Fidgetin-Like-2

  Sharp, D. J.

  9/1/17 → 8/31/21

  Project: Research project

  • Wounds and Injuries 100%
  • Wound Healing 90%
  • Microtubules 80%
  • Cicatrix 35%
  • Small Interfering RNA 34%

• The microtubule cytoskeleton as a novel target for cavernous nerve regeneration after prostatectomy

  Davies, K., Sharp, D. J. & Sharp, D. J.

  4/1/17 → 3/31/21

  Project: Research project

  • Prostatectomy 100%
  • Wounds and Injuries 67%
  • Erectile Dysfunction 59%
  • Small Interfering RNA 58%
  • Nerve Regeneration 50%

• Catalytic and regulatory mechanisms of human Tryptophan Dioxygenase

  Yeh, S.

  6/1/16 → 4/30/22

  Project: Research project

  • Tryptophan 100%
  • N-Formylkynurenine 12%
  • Kynurenine 11%
  • Chemistry 8%
  • Reaction Intermediate 8%

• MECHANISM OF MICROTUBULE DYNAMICS REGULATION BY KINESINS

  Sosa, H. J.

  3/1/15 → 1/31/22

  Project: Research project

  • Kinesin 100%
  • Microtubules 75%
  • Tubulin 27%
  • Polymers 15%
  • Centrioles 12%

• Inhibitors of Purine Import into Plasmodium falciparum Kill Malaria Parasites

  Akabas, M.

  2/1/15 → 1/31/21

  Project: Research project

  • Purine 100%
  • Nucleoside 76%
  • Antimalarial Agent 42%
  • Adenosine 15%
  • Nucleotide 13%

• Cellular Remodeling by Microtubule Severing

  Ross, J., Sharp, D. J., Rose, S. A., Rose, S. A. & Sharp, D. J.

  7/1/14 → 12/31/18

  Project: Research project

  • Microtubules 100%
  • Cell Movement 70%
  • Centrosome 21%
  • Enzymes 14%
  • Human Development 9%

• Einstein Post-baccalaureate Research Education Program

  Akabas, M. & Rose, S. A.

  4/1/13 → 2/28/22

  Project: Research project

  • trainee 100%
  • biomedical research 81%
  • applicant 50%
  • minority 36%
  • club 36%

• MECHANISMS AND MODULATION OF ACCELLULAR HbA TOXICITY

  Alayash, A. I., Friedman, J. M., Intaglietta, M., Nacharaju, P. & Olson, J. S.

  National Heart, Lung, and Blood Institute

  8/1/12 → 8/31/18

  Project: Research project

  • Blood Transfusion 100%
  • Nanoparticles 94%
  • Perfusion 80%
  • Transfusion Medicine 74%
  • Tissue Expansion 74%

• MECHANISMS AND MODULATION OF ACCELLULAR HbA TOXICITY

  Friedman, J. M., Olson, J. S., Alayash, A. I., Intaglietta, M., Nacharaju, P., Olson, J. S. & Alayash, A. I.

  8/1/12 → 8/31/18

  Project: Research project

  • Blood Transfusion 100%
  • Nanoparticles 94%
  • Perfusion 80%
  • Transfusion Medicine 74%
  • Tissue Expansion 74%

• Hb Chemical Modifications and Nanoparticle Production

  Nacharaju, P.

  National Heart, Lung, and Blood Institute

  8/1/12 → 7/31/17

  Project: Research project

  • Nanoparticles 100%
  • Hemoglobins 87%
  • Viscosity 78%
  • Nitrite Reductases 59%
  • Osmotic Pressure 43%

• Phosphoregulation of the Kinesin Motor Domain: Structure, Dynamics and Function

  Gerfen, G. J., Ma, A., Sharp, D. J. & Sosa, H. J.

  National Institute of General Medical Sciences

  5/1/12 → 4/30/16

  Project: Research project

  • Kinesin 100%
  • Phosphorylation 51%
  • Microtubules 18%
  • Hydrolysis 11%
  • Catalytic Domain 11%

• Phosphoregulation of the Kinesin Motor Domain: Structure, Dynamics and Function

  Ma, A. O., Ma, A. O., Sharp, D. J., Gerfen, G. J., Sosa, H. J., Rose, S. A., Rose, S. A., Rose, S. A., Rose, S. A., Rose, S. A., Rose, S. A., Rose, S. A. & Rose, S. A.

  5/1/12 → 4/30/16

  Project: Research project

  • Kinesin 100%
  • Phosphorylation 43%
  • Microtubules 15%
  • Hydrolysis 9%
  • Catalytic Domain 9%

• Mechanisms of Energy Transduction in Heme-Copper Oxidases

  Rousseau, D. L. & Rose, S. A.

  9/20/11 → 8/31/16

  Project: Research project

  • Proton 100%
  • Cytochrome 66%
  • Dioxygen 52%
  • Chemistry 44%
  • Heme 42%

• Production of Bioactive NO: Origin of Hemoglobin E Associated Pathophysiology

  Friedman, J. M., Hirsch, R., Rose, S. A. & Rose, S. A.

  12/15/10 → 7/31/13

  Project: Research project

  • Thalassemia 100%
  • Hemoglobin E 99%
  • Nitric Oxide 83%
  • Nitrites 67%
  • glycosylated-nitric oxide complex hemoglobin A 34%

• Translocation through TonB-dependent transporters

  Jakes, K. S.

  National Institutes of Health

  12/15/10 → 11/30/15

  Project: Research project

  • colicins 100%
  • transporters 95%
  • receptors 84%
  • Yersinia pestis 21%
  • Escherichia coli 20%

• Translocation through TonB-dependent transporters

  Jakes, K. S.

  National Institute of Allergy and Infectious Diseases

  12/15/10 → 11/30/15

  Project: Research project

  • colicins 100%
  • transporters 97%
  • receptors 85%
  • Escherichia coli 21%
  • Yersinia pestis 19%

• Catalytic and Inhibitory Mechanisms in Indoleamine 2,3-dioxygenase

  Yeh, S., Rose, S. A. & Rose, S. A.

  6/1/10 → 4/30/14

  Project: Research project

  • N-Formylkynurenine 100%
  • L-Tryptophan 79%
  • Chemistry 71%
  • Heme 56%
  • Antitumor 56%

• Protein Reactivity in Sol-Gel Matrices: Hydration Effects in Confined Spaces

  Friedman, J. M. & Rose, S. A.

  9/30/09 → 8/31/11

  Project: Research project

  • Proteins 100%
  • Polymethyl Methacrylate 76%
  • Water 67%
  • Gels 55%
  • Confined Spaces 53%

• Structural Basis of Kinesin Motor Movement

  Sosa, H. J. & Rose, S. A.

  9/1/09 → 8/31/14

  Project: Research project

  • Kinesin 100%
  • Microtubules 47%
  • Walkers 28%
  • Catalytic Domain 17%
  • Neoplasms 12%

• Circular Dichroism Spectrometer

  Rousseau, D. L.

  4/1/08 → 3/31/09

  Project: Research project

  • Circular Dichroism 100%
  • Blood Substitutes 77%
  • Synucleins 41%
  • T-Cell Leukemia 36%
  • Clinical Trials 35%

• The Role of Selenium in Intestinal Inflammation and Cancer

  Jelicks, L. A.

  National Institutes of Health

  5/1/07 → 4/30/10

  Project: Research project

  • selenium 100%
  • inflammation 84%
  • neoplasms 78%
  • gastrointestinal system 74%
  • animal models 48%

• The Role of Selenium in Intestinal Inflammation and Cancer

  Jelicks, L. A.

  National Cancer Institute

  5/1/07 → 4/30/10

  Project: Research project

  • selenium 100%
  • inflammation 84%
  • neoplasms 78%
  • gastrointestinal system 74%
  • animal models 48%

• Proton Crystallography of Membrane Proteins Using High Frequency ENDOR

  Gerfen, G. J. & Rose, S. A.

  9/1/06 → 8/31/10

  Project: Research project

  • proteins 100%
  • membranes 73%
  • crystallography 56%
  • electrons 31%
  • crystals 24%

• Proton Crystallography of Membrane Proteins Using High Frequency ENDOR

  Gerfen, G. J.

  National Institute of General Medical Sciences

  9/1/06 → 8/31/10

  Project: Research project

  • crystallography 100%
  • proteins 70%
  • membranes 64%
  • protons 57%
  • membrane proteins 53%

• Propofol Interactions with GABA-A Receptors

  Akabas, M. & Rose, S. A.

  5/1/06 → 4/30/11

  Project: Research project

  • Propofol 100%
  • GABA-A Receptors 60%
  • General Anesthetics 59%
  • General Anesthesia 25%
  • Anesthetics 24%

• Catalytic Properties of Cytochrome Oxidase

  Rousseau, D. L. & Rose, S. A.

  9/3/05 → 8/31/10

  Project: Research project

  • Cytochrome 100%
  • Proton 53%
  • Absorptivity 31%
  • Chemistry 28%
  • Resonance 26%

• Malaria PfCRT Transporter: Structure, Function, Sorting

  Akabas, M. & Rose, S. A.

  3/1/05 → 2/28/08

  Project: Research project

  • Plasmodium falciparum PfCRT protein 100%
  • Chloroquine 12%
  • Membranes 10%
  • Parasites 9%
  • Vacuoles 7%

• TrHbs: Biophysical Consequences of a Nonpolar Tunnel

  Friedman, J. M. & Rose, S. A.

  7/15/04 → 6/30/08

  Project: Research project

  • Truncated Hemoglobins 100%
  • Hydrogen Bonding 30%
  • Spectrum Analysis 24%
  • Photolysis 17%
  • Ligands 17%

• Core B- Administrative Core

  Briehl, R. W.

  National Heart, Lung, and Blood Institute

  7/1/04 → 6/30/05

  Project: Research project

• MRI METHODS FOR ANALYSIS OF BLADDER AND GI TRACT IN MICE

  Jelicks, L. A.

  National Institutes of Health

  6/1/04 → 5/31/07

  Project: Research project

  • magnetic resonance imaging 100%
  • bladder 99%
  • Chagas disease 90%
  • gastrointestinal system 78%
  • mice 40%

• MRI METHODS FOR ANALYSIS OF BLADDER AND GI TRACT IN MICE

  Jelicks, L. A.

  National Institute of Allergy and Infectious Diseases

  6/1/04 → 5/31/07

  Project: Research project

  • magnetic resonance imaging 100%
  • bladder 99%
  • Chagas disease 90%
  • gastrointestinal system 78%
  • mice 40%

• Early Events in Protein Folding

  Rousseau, D. L. & Rose, S. A.

  5/1/03 → 4/30/08

  Project: Research project

  • Myoglobin 100%
  • Protein Folding 93%
  • Cytochromes c 85%
  • Proteins 72%
  • Sperm Whale 69%

• Microtubule Motor-Mechanisms of Chromosome Movements

  Sharp, D. J. & Rose, S. A.

  8/15/02 → 5/31/11

  Project: Research project

  • Chromosomes 100%
  • Microtubules 36%
  • Kinetochores 33%
  • Metaphase 28%
  • Dynactin Complex 19%

• New Paradigms in the Design of Blood Substitutes

  Friedman, J. M., Peisach, J., Chien, H., Manjula, B., Intaglietta, M. & Acharya, S. A.

  8/5/02 → 7/31/08

  Project: Research project

  • hemoglobin 100%
  • oxygen 72%
  • polyethylene glycol 25%
  • physiology 20%
  • testing 15%

• STRUCTURAL BASIS OF KINESIN MOTOR MOVEMENT

  Sosa, H. J. & Rose, S. A.

  7/1/02 → 6/30/07

  Project: Research project

  • Kinesin 100%
  • Microtubules 28%
  • Adenosine Triphosphate 26%
  • Hydrolysis 13%
  • Hand 7%

• BIOPHYSICAL EVALUATION OF SOL-GEL ENCAPSULATED PROTEINS

  Friedman, J. M.

  3/1/02 → 12/31/06

  Project: Research project

  • Heme 100%
  • Encapsulation 93%
  • Protein 89%
  • Resonance 42%
  • IR Absorption 31%

• Structure Function Relationship in Hemeproteins

  Yeh, S. & Rose, S. A.

  12/1/01 → 5/31/06

  Project: Research project

  • hemoglobin 100%
  • heme 41%
  • heme proteins 36%
  • peroxidases 30%
  • structure-activity relationships 28%

• ANESTHETIC MECHANISMS AND GABA-A RECEPTOR STRUCTURE

  Akabas, M.

  9/1/00 → 8/31/03

  Project: Research project

  • GABA Receptors 100%
  • Binding Sites 79%
  • Crystallization 74%
  • GABA-A Receptors 66%
  • gamma-Aminobutyric Acid 59%

• BIOPHYSICAL EVALUATION OF SOL-GEL ENCAPSULATED PROTEINS

  Friedman, J. M.

  3/1/00 → 2/28/02

  Project: Research project

  • Heme 100%
  • Encapsulation 93%
  • Protein 89%
  • Resonance 42%
  • IR Absorption 31%

• ADVANCED EPR STUDIES OF B12 DEPENDENT ENZYMES

  Gerfen, G. J. & Rose, S. A.

  2/1/00 → 1/31/06

  Project: Research project

  • Ribonucleoside Triphosphate 100%
  • Dimethylbenzimidazole 54%
  • Cobalamin 43%
  • Electron-Nuclear Double Resonance Spectroscopy 42%
  • Spin Echo 40%

• ADVANCED EPR STUDIES OF B12 DEPENDENT ENZYMES

  Gerfen, G. J.

  National Institute of General Medical Sciences

  2/1/00 → 1/31/05

  Project: Research project

  • Ribonucleoside Triphosphate 100%
  • EPR Spectroscopy 71%
  • Dimethylbenzimidazole 54%
  • Cobalamin 43%
  • Electron-Nuclear Double Resonance Spectroscopy 42%

• HEMOGLOBIN--A WORKBENCH TO STUDY PROTEIN ALLOSTERY

  Friedman, J. M., Englander, S., Noble, R., Hoffman, B., Armone, A., Arnone, A. & Englander, S.

  1/1/99 → 12/31/05

  Project: Research project

  • Ligation 100%
  • Hemoglobins 91%
  • Proteins 69%
  • Thermodynamics 46%
  • Heme 41%

• MECHANISMS OF CELLULAR IRON UPTAKE FROM TRANSFERRIN

  Friedman, J. M., Wessling-Resnick, M., Enns, C., Aisen, P. & Schlisky, M.

  10/1/98 → 4/30/06

  Project: Research project

  • Transferrin 100%
  • Iron 84%
  • Transferrin Receptors 41%
  • Hepatocytes 14%
  • Endosomes 9%

• MOTOR PROTEIN FUNCTION DURING MITOSIS

  Sharp, D. J.

  1/1/98 → 12/31/00

  Project: Research project

  • Spindle Apparatus 100%
  • Microtubules 98%
  • Cytoplasmic Dyneins 61%
  • Mitosis 39%
  • Drosophila 37%

• STRUCTURE INTERACTION AND MECHANISM IN SICKLE HEMOGLOBIN

  Briehl, R. W., Ferrone, F., Josephs, R., Manning, J. & Bookchin, R.

  8/6/97 → 12/31/08

  Project: Research project

  • hemoglobin 100%
  • gelation 94%
  • sickle cell anemia 85%
  • gels 79%
  • pathophysiology 71%