TY - JOUR
T1 - 感染8型人类疱疹病毒后的DNA阳性与低胰岛素分泌相关:一项对撒哈拉沙漠以南的非洲糖尿病患者的病例对照研究
AU - Lontchi-Yimagou, Eric
AU - Legoff, Jérôme
AU - Nguewa, Jean Louis
AU - Boudou, Philippe
AU - Balti, Eric V.
AU - Noubiap, Jean J.
AU - Kamwa, Vicky
AU - Atogho-Tiedeu, Barbara
AU - Azabji-Kenfack, Marcel
AU - Djahmeni, Eric N.
AU - Etoa, Martine
AU - Lemdjo, Gaelle
AU - Balla, Vanessa
AU - Dehayem, Mesmin Y.
AU - Foufelle, Fabienne
AU - Mbanya, Jean Claude
AU - Gautier, Jean Francois
AU - Sobngwi, Eugene
N1 - Funding Information:
The authors are grateful to all those who participated in the study. ELY received a fellowship grant from L’Institut Servier and from the Service of Action and Cooperation of the French Embassy in Cameroon.
Publisher Copyright:
© 2018 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and John Wiley & Sons Australia, Ltd
PY - 2018/11
Y1 - 2018/11
N2 - Background: Viruses have been considered potential triggers for the development of diabetes. This study assessed insulin secretion and insulin sensitivity in human herpesvirus 8 (HHV8)-infected and uninfected sub-Saharan African people with diabetes. Methods: In all, 173 people with non-autoimmune diabetes were enrolled consecutively: 124 with type 2 diabetes mellitus (T2DM) and 49 with ketosis-prone diabetes (KPD) admitted in hyperglycemic crisis. Those with KPD were further subdivided into those with new-onset ketotic-phase KPD (n = 34) or non-ketotic phase KPD (n = 15). All participants were screened for HHV8-specific antibodies and genomic DNA. Blood samples were collected for analysis of fasting glucose, HbA1c, lipid profile, and C-peptide, with insulin resistance and secretion estimated by homeostasis model assessment. Results: Among the 173 diabetic participants, 88 (50.9%) were positive for HHV8 antibodies (Ac-HHV8+), including 15 (8.7%) positive for HHV8 DNA (DNA-HHV8+). The seroprevalence of HHV8 was similar between T2DM (55.6%) and KPD (61.2%) subjects. Of those with and without ketotic-phase KPD, 35.3% and 46.7% were Ac-HHV8+, respectively. Body mass index was significantly in lower DNA-HHV8+ than DNA-HHV8– subjects. Low-density lipoprotein and total cholesterol were significantly higher, but C-peptide and homeostatic model assessment of β-cell function (HOMA-β) were significantly lower in DNA-HHV8+ than DNA-HHV8– participants. After excluding DNA-HHV8+ participants, triglyceride concentrations were significantly higher in Ac-HHV8+ (n = 73) than Ac-HHV8– (n = 85) subjects. In contrast, HOMA-β was significantly higher among Ac-HHV8+ than Ac-HHV8– participants. Conclusions: In the present study, HHV8 DNA positivity was associated with low insulin secretion in this sub-Saharan African diabetes population.
AB - Background: Viruses have been considered potential triggers for the development of diabetes. This study assessed insulin secretion and insulin sensitivity in human herpesvirus 8 (HHV8)-infected and uninfected sub-Saharan African people with diabetes. Methods: In all, 173 people with non-autoimmune diabetes were enrolled consecutively: 124 with type 2 diabetes mellitus (T2DM) and 49 with ketosis-prone diabetes (KPD) admitted in hyperglycemic crisis. Those with KPD were further subdivided into those with new-onset ketotic-phase KPD (n = 34) or non-ketotic phase KPD (n = 15). All participants were screened for HHV8-specific antibodies and genomic DNA. Blood samples were collected for analysis of fasting glucose, HbA1c, lipid profile, and C-peptide, with insulin resistance and secretion estimated by homeostasis model assessment. Results: Among the 173 diabetic participants, 88 (50.9%) were positive for HHV8 antibodies (Ac-HHV8+), including 15 (8.7%) positive for HHV8 DNA (DNA-HHV8+). The seroprevalence of HHV8 was similar between T2DM (55.6%) and KPD (61.2%) subjects. Of those with and without ketotic-phase KPD, 35.3% and 46.7% were Ac-HHV8+, respectively. Body mass index was significantly in lower DNA-HHV8+ than DNA-HHV8– subjects. Low-density lipoprotein and total cholesterol were significantly higher, but C-peptide and homeostatic model assessment of β-cell function (HOMA-β) were significantly lower in DNA-HHV8+ than DNA-HHV8– participants. After excluding DNA-HHV8+ participants, triglyceride concentrations were significantly higher in Ac-HHV8+ (n = 73) than Ac-HHV8– (n = 85) subjects. In contrast, HOMA-β was significantly higher among Ac-HHV8+ than Ac-HHV8– participants. Conclusions: In the present study, HHV8 DNA positivity was associated with low insulin secretion in this sub-Saharan African diabetes population.
KW - human herpesvirus type 8
KW - insulin resistance
KW - insulin secretion
KW - ketosis-pronediabetes
KW - type 2 diabetes
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U2 - 10.1111/1753-0407.12777
DO - 10.1111/1753-0407.12777
M3 - Article
C2 - 29707905
AN - SCOPUS:85047746012
SN - 1753-0393
VL - 10
SP - 866
EP - 873
JO - Journal of Diabetes
JF - Journal of Diabetes
IS - 11
ER -
