TY - JOUR
T1 - Zipcode binding protein 1 (ZBP1; IGF2BP1)
T2 - A model for sequence-specific RNA regulation
AU - Biswas, Jeetayu
AU - Nunez, Leti
AU - Das, Sulagna
AU - Yoon, Young J.
AU - Eliscovich, Carolina
AU - Singer, Robert H.
N1 - Publisher Copyright:
© 2019 Biswas et al.
PY - 2019
Y1 - 2019
N2 - The fate of an RNA, from its localization, translation, and ultimate decay, is dictated by interactions with RNA binding proteins (RBPs). β-actin mRNA has functioned as the classic example of RNA localization in eukaryotic cells. Studies of β-actin mRNA over the past three decades have allowed understanding of how RBPs, such as ZBP1 (IGF2BP1), can control both RNA localization and translational status. Here, we summarize studies of β-actin mRNA and focus on how ZBP1 serves as a model for understanding interactions between RNA and their binding protein(s). Central to the study of RNA and RBPs were technological developments that occurred along the way. We conclude with a future outlook highlighting new technologies that may be used to address still unanswered questions about RBP-mediated regulation of mRNA during its life cycle, within the cell.
AB - The fate of an RNA, from its localization, translation, and ultimate decay, is dictated by interactions with RNA binding proteins (RBPs). β-actin mRNA has functioned as the classic example of RNA localization in eukaryotic cells. Studies of β-actin mRNA over the past three decades have allowed understanding of how RBPs, such as ZBP1 (IGF2BP1), can control both RNA localization and translational status. Here, we summarize studies of β-actin mRNA and focus on how ZBP1 serves as a model for understanding interactions between RNA and their binding protein(s). Central to the study of RNA and RBPs were technological developments that occurred along the way. We conclude with a future outlook highlighting new technologies that may be used to address still unanswered questions about RBP-mediated regulation of mRNA during its life cycle, within the cell.
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U2 - 10.1101/sqb.2019.84.039396
DO - 10.1101/sqb.2019.84.039396
M3 - Article
C2 - 32086331
AN - SCOPUS:85088611204
SN - 0091-7451
VL - 84
SP - 1
EP - 10
JO - Cold Spring Harbor symposia on quantitative biology
JF - Cold Spring Harbor symposia on quantitative biology
ER -