Zipcode binding protein 1 (ZBP1; IGF2BP1): A model for sequence-specific RNA regulation

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9 Scopus citations


The fate of an RNA, from its localization, translation, and ultimate decay, is dictated by interactions with RNA binding proteins (RBPs). β-actin mRNA has functioned as the classic example of RNA localization in eukaryotic cells. Studies of β-actin mRNA over the past three decades have allowed understanding of how RBPs, such as ZBP1 (IGF2BP1), can control both RNA localization and translational status. Here, we summarize studies of β-actin mRNA and focus on how ZBP1 serves as a model for understanding interactions between RNA and their binding protein(s). Central to the study of RNA and RBPs were technological developments that occurred along the way. We conclude with a future outlook highlighting new technologies that may be used to address still unanswered questions about RBP-mediated regulation of mRNA during its life cycle, within the cell.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalCold Spring Harbor symposia on quantitative biology
StatePublished - 2019

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics


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