Zebrafish cytosolic carboxypeptidases 1 and 5 are essential for embryonic development

Peter J. Lyons; Matthew R. Sapio; Lloyd D. Fricker

doi:10.1074/jbc.M113.497933

Zebrafish cytosolic carboxypeptidases 1 and 5 are essential for embryonic development

Peter J. Lyons, Matthew R. Sapio, Lloyd D. Fricker

Molecular Pharmacology

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Background: Cytosolic carboxypeptidases (CCPs) are a subfamily of enzymes that modify tubulin. Results: Zebrafish CCPs exhibit overlapping expression in developing organs. Knockdown of CCP1 and CCP5 results in similar defects including severe hydrocephalus and axial curvature. Conclusion: Loss of deglutamylating enzymes causes developmental defects in zebrafish. Significance: CCP1 and CCP5 play important roles in zebrafish embryonic development.

Original language	English (US)
Pages (from-to)	30454-30462
Number of pages	9
Journal	Journal of Biological Chemistry
Volume	288
Issue number	42
DOIs	https://doi.org/10.1074/jbc.M113.497933
State	Published - Oct 18 2013

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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abstract = "Background: Cytosolic carboxypeptidases (CCPs) are a subfamily of enzymes that modify tubulin. Results: Zebrafish CCPs exhibit overlapping expression in developing organs. Knockdown of CCP1 and CCP5 results in similar defects including severe hydrocephalus and axial curvature. Conclusion: Loss of deglutamylating enzymes causes developmental defects in zebrafish. Significance: CCP1 and CCP5 play important roles in zebrafish embryonic development.",

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AU - Lyons, Peter J.

AU - Sapio, Matthew R.

AU - Fricker, Lloyd D.

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Y1 - 2013/10/18

N2 - Background: Cytosolic carboxypeptidases (CCPs) are a subfamily of enzymes that modify tubulin. Results: Zebrafish CCPs exhibit overlapping expression in developing organs. Knockdown of CCP1 and CCP5 results in similar defects including severe hydrocephalus and axial curvature. Conclusion: Loss of deglutamylating enzymes causes developmental defects in zebrafish. Significance: CCP1 and CCP5 play important roles in zebrafish embryonic development.

AB - Background: Cytosolic carboxypeptidases (CCPs) are a subfamily of enzymes that modify tubulin. Results: Zebrafish CCPs exhibit overlapping expression in developing organs. Knockdown of CCP1 and CCP5 results in similar defects including severe hydrocephalus and axial curvature. Conclusion: Loss of deglutamylating enzymes causes developmental defects in zebrafish. Significance: CCP1 and CCP5 play important roles in zebrafish embryonic development.

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Zebrafish cytosolic carboxypeptidases 1 and 5 are essential for embryonic development

Abstract

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