XSkin-derived cues control arborization of sensory dendrites in Caenorhabditis elegans

Yehuda Salzberg, Carlos A. Díaz-Balzac, Nelson J. Ramirez-Suarez, Matthew Attreed, Eillen Tecle, Muriel Desbois, Zaven Kaprielian, Hannes E. Bülow

Research output: Contribution to journalArticlepeer-review

115 Scopus citations


Sensory dendrites depend on cues from their environment to pattern their growth and direct them toward their correct target tissues. Yet, little is known about dendrite-substrate interactions during dendrite morphogenesis. Here, we describe MNR-1/menorin, which is part of the conserved Fam151 family of proteins and is expressed in the skin to control the elaboration of "menorah"- like dendrites of mechanosensory neurons in Caenorhabditis elegans. We provide biochemical and genetic evidence that MNR-1 acts as a contact-dependent or short-range cue in concert with the neural cell adhesion molecule SAX-7/L1CAM in the skin and through the neuronal leucine-rich repeat transmembrane receptor DMA-1 on sensory dendrites. Our data describe an unknown pathway that provides spatial information from the skin substrate to pattern sensory dendrite development nonautonomously.

Original languageEnglish (US)
Pages (from-to)308
Number of pages1
Issue number2
StatePublished - Oct 10 2013

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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