What Can We Model?

Models are representations that researchers use to create knowledge. There remains much to learn about seizures and epilepsy. Consequently, a wide variety of models could be helpful. As the contents of the 2nd Edition of Models of Seizures and Epilepsy show, we have a respectable roster of in silico, in vitro, as well as nonmammalian and mammalian in vivo models of seizures and epilepsy that can be used to investigate different aspects of the mechanisms of epileptic spikes, epileptiform discharges, epileptogenic networks, seizures, status epilepticus, epilepsy, and related comorbidities at different developmental ages and genders.