Virus membrane-fusion proteins: More than one way to make a hairpin

Margaret Kielian, Félix A. Rey

Research output: Contribution to journalReview articlepeer-review

451 Scopus citations


Structure-function studies have defined two classes of viral membrane-fusion proteins that have radically different architectures but adopt a similar overall 'hairpin' conformation to induce fusion of the viral and cellular membranes and therefore initiate infection. In both classes, the hairpin conformation is achieved after a conformational change is triggered by interaction with the target cell. This review will focus in particular on the properties of the more recently described class II proteins.

Original languageEnglish (US)
Pages (from-to)67-76
Number of pages10
JournalNature Reviews Microbiology
Issue number1
StatePublished - Jan 2006

ASJC Scopus subject areas

  • Microbiology
  • Immunology and Microbiology(all)
  • Infectious Diseases


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