Ventral intermediate thalamic stimulation for monoclonal gammopathy-associated tremor: Case report

Donald C. Shields, Alice W. Flaherty, Emad N. Eskandar, Ziv M. Williams

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


BACKGROUND AND IMPORTANCE: Peripheral and central sensory loss are often associated with significant tremor or sensory ataxia, which can be highly refractory to medical therapy. CLINICAL PRESENTATION: We present the case of a 67-year-old man with progressive and debilitating intention tremor from monoclonal gammopathy-associated peripheral neuropathy. The patient was implanted with bilateral thalamic deep brain stimulator electrodes under microelectrode guidance. Following optimization of stimulation parameters, the patient's appendicular tremor and gait improved, as did his general activities of daily living. CONCLUSION: These initial findings suggest that deep brain stimulation may benefit not only tremor presumed to originate from central nervous system dysfunction, but also tremor originating peripherally from neuropathy-related sensory loss.

Original languageEnglish (US)
Pages (from-to)E1464-E1467
Issue number5
StatePublished - May 2011
Externally publishedYes


  • Action tremor
  • Deep brain stimulation
  • Microelectrode recording
  • Monoclonal gammopathy
  • Polyneuropathy
  • Thalamus

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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