Validity and responsiveness of generic preference-based HRQOL instruments in chronic epilepsy

J. T. Langfitt; B. G. Vickrey; M. P. McDermott; S. Messing; A. T. Berg; S. S. Spencer; M. R. Sperling; C. W. Bazil; S. Shinnar

doi:10.1007/s11136-005-5231-3

Validity and responsiveness of generic preference-based HRQOL instruments in chronic epilepsy

J. T. Langfitt, B. G. Vickrey, M. P. McDermott, S. Messing, A. T. Berg, S. S. Spencer, M. R. Sperling, C. W. Bazil, S. Shinnar

Neurology

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

Generic, preference-based instruments are recommended for assessing health-related quality of life (HRQOL) in cost-utility analyses (CUA). We aimed to determine which instrument is the most appropriate for CUA of epilepsy care, using established psychometric criteria. We compared validity and responsiveness of EQ5D (using both UK and US preferences), visual analog scale (VAS), Health Utilities Index Mark II (HUI-2) and Mark III (HUI-3) and SF6D in 165 adults evaluated for epilepsy surgery. SF6D had the strongest or next-strongest associations with seizure severity and seizure control. It was not associated with education or IQ. Only SF6D and HUI-3 discriminated between patients with and without seizures 2 years after baseline evaluation. SF6D was most or next-most responsive to being seizure-free for 2 years, in most responsiveness analyses. VAS was also responsive, but showed less evidence of validity. The QOLIE-89, an epilepsy-targeted profile instrument, had stronger evidence for validity and responsiveness than the preference instruments. SF6D has several key psychometric advantages over four other preference instruments in CUAs of epilepsy care. This may reflect better coverage of HRQOL dimensions affected by epilepsy, greater sensitivity at the upper end of the HRQOL continuum, or both. These findings may not generalize to other chronic conditions.

Original language	English (US)
Pages (from-to)	899-914
Number of pages	16
Journal	Quality of Life Research
Volume	15
Issue number	5
DOIs	https://doi.org/10.1007/s11136-005-5231-3
State	Published - May 2006

Keywords

Epilepsy
Preference
Responsiveness
Utility
Validity

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s11136-005-5231-3

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title = "Validity and responsiveness of generic preference-based HRQOL instruments in chronic epilepsy",

abstract = "Generic, preference-based instruments are recommended for assessing health-related quality of life (HRQOL) in cost-utility analyses (CUA). We aimed to determine which instrument is the most appropriate for CUA of epilepsy care, using established psychometric criteria. We compared validity and responsiveness of EQ5D (using both UK and US preferences), visual analog scale (VAS), Health Utilities Index Mark II (HUI-2) and Mark III (HUI-3) and SF6D in 165 adults evaluated for epilepsy surgery. SF6D had the strongest or next-strongest associations with seizure severity and seizure control. It was not associated with education or IQ. Only SF6D and HUI-3 discriminated between patients with and without seizures 2 years after baseline evaluation. SF6D was most or next-most responsive to being seizure-free for 2 years, in most responsiveness analyses. VAS was also responsive, but showed less evidence of validity. The QOLIE-89, an epilepsy-targeted profile instrument, had stronger evidence for validity and responsiveness than the preference instruments. SF6D has several key psychometric advantages over four other preference instruments in CUAs of epilepsy care. This may reflect better coverage of HRQOL dimensions affected by epilepsy, greater sensitivity at the upper end of the HRQOL continuum, or both. These findings may not generalize to other chronic conditions.",

keywords = "Epilepsy, Preference, Responsiveness, Utility, Validity",

author = "Langfitt, {J. T.} and Vickrey, {B. G.} and McDermott, {M. P.} and S. Messing and Berg, {A. T.} and Spencer, {S. S.} and Sperling, {M. R.} and Bazil, {C. W.} and S. Shinnar",

note = "Funding Information: Supported by RO1 HS09986 (Agency for Healthcare Research and Quality) and RO1 NS32375 (NINDS). The authors gratefully acknowledge the assistance of Greta Johnston, Stephen Mat-ics, Kim Hart, Christopher Smith and Gloria Sheu in data collection and the comments of David Feeny and two anonymous reviewers. Results were previously presented at the Annual Meeting of the American Epilepsy Society, Boston, MA, December, 2003.",

year = "2006",

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doi = "10.1007/s11136-005-5231-3",

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AU - Messing, S.

AU - Berg, A. T.

AU - Spencer, S. S.

AU - Sperling, M. R.

AU - Bazil, C. W.

AU - Shinnar, S.

N1 - Funding Information: Supported by RO1 HS09986 (Agency for Healthcare Research and Quality) and RO1 NS32375 (NINDS). The authors gratefully acknowledge the assistance of Greta Johnston, Stephen Mat-ics, Kim Hart, Christopher Smith and Gloria Sheu in data collection and the comments of David Feeny and two anonymous reviewers. Results were previously presented at the Annual Meeting of the American Epilepsy Society, Boston, MA, December, 2003.

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KW - Validity

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Validity and responsiveness of generic preference-based HRQOL instruments in chronic epilepsy

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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