Validity and reliability of the migraine-treatment optimization questionnaire

R. B. Lipton, K. Kolodner, M. E. Bigal, D. Valade, M. J.A. Láinez, J. Pascual, A. Gendolla, G. Bussone, N. Islam, K. Albert, B. Parsons

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


Our aim was to establish the validity and reliability of a patient-rated Migraine Treatment Optimization Questionnaire (M-TOQ) in primary care. Patients who met International Classification of Headache Disorders, 2nd edn criteria for migraine completed a 19-item questionnaire containing candidate items for the M-TOQ, and three questionnaires designed to test convergent/construct validity [Migraine Disability Assessment Scale (MIDAS), Headache Impact Test (HIT)-6 and Migraine-Specific Quality of Life Scale (MSQoL)]. A 15-item (M-TOQ-15) and a five-item (M-TOQ-5) questionnaire were derived. Two hundred and fifty-three adult patients were recruited. Five treatment optimization domains were identified: functioning, rapid relief, consistency of relief, risk of recurrence and tolerability; with Cronbach alphas of 0.70-0.84. The Cronbach α for M-TOQ-15 was 0.85, and it correlated well with MIDAS, HIT-6 and MSQoL (r = 0.33-0.44). The Cronbach α for M-TOQ-5 was 0.66, and it also correlated well with the three questionnaires (r = 0.33-0.41). The utility of the M-TOQ for assessing treatment benefit in research (M-TOQ-15) and primary care (M-TOQ-5) should be further validated.

Original languageEnglish (US)
Pages (from-to)751-759
Number of pages9
Issue number7
StatePublished - Jul 2009


  • Migraine
  • Reliability
  • Treatment optimization
  • Validity

ASJC Scopus subject areas

  • Clinical Neurology


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