Use of positive airway pressure in mild cognitive impairment to delay progression to dementia

Virginia Skiba, Marina Novikova, Aarushi Suneja, Beth McLellan, Lonni Schultz

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Study Objectives: The aim was to assess the relationship between continuous positive airway pressure (CPAP) therapy and cognitive function in patients with mild cognitive impairment (MCI) and obstructive sleep apnea (OSA). Methods: This was a retrospective chart reviewof patientswithMCI andOSA.CPAP therapy compliance was defined as average use ofCPAP therapy for at least 4 hours per night. Kaplan-Meier estimates, log-rank tests, and Cox proportional hazards regression were done to compare the compliance groups in terms of progression to dementia, defined as a Clinical Dementia Rating of 1 or greater. Linear mixed models were used to assess the relationships between CPAP therapy compliance and neurological cognitive function outcomes over time. Results: Ninety-six patients were included with mean age at MCI diagnosis of 70.4 years, mean apnea-hypopnea index of 25.9 events/h, and mean duration of neurology follow-up of 2.8 years. Forty-two were CPAP compliant, 30 were noncompliant, and 24 had no CPAP use. No overall difference between the groups was detected for progression to dementia (P =.928, log-rank test). Patients with amnestic MCI had better CPAP use (P =.016) and shorter progression time to dementia (P = .042), but this difference was not significant after adjusting for age, education, and race (P = .32). Conclusions: CPAP use in patients with MCI and OSA was not associated with delay in progression to dementia or cognitive decline.

Original languageEnglish (US)
Pages (from-to)863-870
Number of pages8
JournalJournal of Clinical Sleep Medicine
Issue number6
StatePublished - Jun 15 2020
Externally publishedYes


  • Continuous positive airway pressure
  • Dementia
  • Mild cognitive impairment
  • Sleep apnea

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Neurology
  • Clinical Neurology


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