Use of ethotoin in phenytoin-related hypersensitivity reactions

Alan B. Ettinger, Solomon L. Moshé, Mark J. Sinnett, Juan C. Canton, Shlomo Shinnar

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Hypersensitivity reactions to phenytoin (PHT) usually result in abandoning the use of hydantoin compounds in the treatment of epilepsy. We report two cases of patients experiencing allergic reactions to PHT who were successfully switched to a related phenylhydantoin, ethotoin, and who remained free of hypersensitivity reactions. Potential mechanisms for differences in hypersensitivity are discussed.

Original languageEnglish (US)
Pages (from-to)29-31
Number of pages3
JournalJournal of Epilepsy
Issue number1
StatePublished - 1993


  • Anticonvulsants
  • Ethotoin
  • Hypersensitivity
  • Phenylhydantoin

ASJC Scopus subject areas

  • General Neuroscience
  • Clinical Neurology


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