Unlocking the Secrets of Mitochondria in the Cardiovascular System: Path to a Cure in Heart Failure—A Report from the 2018 National Heart, Lung, and Blood Institute Workshop

Rong Tian; Wilson S. Colucci; Zoltan Arany; Markus M. Bachschmid; Scott W. Ballinger; Sihem Boudina; James E. Bruce; David W. Busija; Sergey Dikalov; Gerald W. Dorn; Zorina S. Galis; Roberta A. Gottlieb; Daniel P. Kelly; Richard N. Kitsis; Mark J. Kohr; Daniel Levy; E. Douglas Lewandowski; Joseph M. McClung; Daria Mochly-Rosen; Kevin D. O'Brien; Brian O'Rourke; Joon Young Park; Peipei Ping; Michael N. Sack; Shey Shing Sheu; Yang Shi; Sruti Shiva; Douglas C. Wallace; Robert G. Weiss; Hilary J. Vernon; Renee Wong; Lisa Schwartz Longacre

doi:10.1161/circulationaha.119.040551

Unlocking the Secrets of Mitochondria in the Cardiovascular System: Path to a Cure in Heart Failure—A Report from the 2018 National Heart, Lung, and Blood Institute Workshop

Rong Tian, Wilson S. Colucci, Zoltan Arany, Markus M. Bachschmid, Scott W. Ballinger, Sihem Boudina, James E. Bruce, David W. Busija, Sergey Dikalov, Gerald W. Dorn, Zorina S. Galis, Roberta A. Gottlieb, Daniel P. Kelly, Richard N. Kitsis, Mark J. Kohr, Daniel Levy, E. Douglas Lewandowski, Joseph M. McClung, Daria Mochly-Rosen, Kevin D. O'BrienBrian O'Rourke, Joon Young Park, Peipei Ping, Michael N. Sack, Shey Shing Sheu, Yang Shi, Sruti Shiva, Douglas C. Wallace, Robert G. Weiss, Hilary J. Vernon, Renee Wong, Lisa Schwartz Longacre

Medicine

Research output: Contribution to journal › Review article › peer-review

80 Scopus citations

Abstract

Mitochondria have emerged as a central factor in the pathogenesis and progression of heart failure, and other cardiovascular diseases, as well, but no therapies are available to treat mitochondrial dysfunction. The National Heart, Lung, and Blood Institute convened a group of leading experts in heart failure, cardiovascular diseases, and mitochondria research in August 2018. These experts reviewed the current state of science and identified key gaps and opportunities in basic, translational, and clinical research focusing on the potential of mitochondria-based therapeutic strategies in heart failure. The workshop provided short- and long-term recommendations for moving the field toward clinical strategies for the prevention and treatment of heart failure and cardiovascular diseases by using mitochondria-based approaches.

Original language	English (US)
Pages (from-to)	1205-1216
Number of pages	12
Journal	Circulation
Volume	140
Issue number	14
DOIs	https://doi.org/10.1161/circulationaha.119.040551
State	Published - Oct 1 2019

Keywords

cardiovascular diseases
heart failure
mitochondria

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Physiology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1161/circulationaha.119.040551

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Tian, R., Colucci, W. S., Arany, Z., Bachschmid, M. M., Ballinger, S. W., Boudina, S., Bruce, J. E., Busija, D. W., Dikalov, S., Dorn, G. W., Galis, Z. S., Gottlieb, R. A., Kelly, D. P., Kitsis, R. N., Kohr, M. J., Levy, D., Lewandowski, E. D., McClung, J. M., Mochly-Rosen, D., ... Schwartz Longacre, L. (2019). Unlocking the Secrets of Mitochondria in the Cardiovascular System: Path to a Cure in Heart Failure—A Report from the 2018 National Heart, Lung, and Blood Institute Workshop. Circulation, 140(14), 1205-1216. https://doi.org/10.1161/circulationaha.119.040551

Tian, R, Colucci, WS, Arany, Z, Bachschmid, MM, Ballinger, SW, Boudina, S, Bruce, JE, Busija, DW, Dikalov, S, Dorn, GW, Galis, ZS, Gottlieb, RA, Kelly, DP, Kitsis, RN, Kohr, MJ, Levy, D, Lewandowski, ED, McClung, JM, Mochly-Rosen, D, O'Brien, KD, O'Rourke, B, Park, JY, Ping, P, Sack, MN, Sheu, SS, Shi, Y, Shiva, S, Wallace, DC, Weiss, RG, Vernon, HJ, Wong, R & Schwartz Longacre, L 2019, 'Unlocking the Secrets of Mitochondria in the Cardiovascular System: Path to a Cure in Heart Failure—A Report from the 2018 National Heart, Lung, and Blood Institute Workshop', Circulation, vol. 140, no. 14, pp. 1205-1216. https://doi.org/10.1161/circulationaha.119.040551

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title = "Unlocking the Secrets of Mitochondria in the Cardiovascular System: Path to a Cure in Heart Failure—A Report from the 2018 National Heart, Lung, and Blood Institute Workshop",

abstract = "Mitochondria have emerged as a central factor in the pathogenesis and progression of heart failure, and other cardiovascular diseases, as well, but no therapies are available to treat mitochondrial dysfunction. The National Heart, Lung, and Blood Institute convened a group of leading experts in heart failure, cardiovascular diseases, and mitochondria research in August 2018. These experts reviewed the current state of science and identified key gaps and opportunities in basic, translational, and clinical research focusing on the potential of mitochondria-based therapeutic strategies in heart failure. The workshop provided short- and long-term recommendations for moving the field toward clinical strategies for the prevention and treatment of heart failure and cardiovascular diseases by using mitochondria-based approaches.",

keywords = "cardiovascular diseases, heart failure, mitochondria",

author = "Rong Tian and Colucci, {Wilson S.} and Zoltan Arany and Bachschmid, {Markus M.} and Ballinger, {Scott W.} and Sihem Boudina and Bruce, {James E.} and Busija, {David W.} and Sergey Dikalov and Dorn, {Gerald W.} and Galis, {Zorina S.} and Gottlieb, {Roberta A.} and Kelly, {Daniel P.} and Kitsis, {Richard N.} and Kohr, {Mark J.} and Daniel Levy and Lewandowski, {E. Douglas} and McClung, {Joseph M.} and Daria Mochly-Rosen and O'Brien, {Kevin D.} and Brian O'Rourke and Park, {Joon Young} and Peipei Ping and Sack, {Michael N.} and Sheu, {Shey Shing} and Yang Shi and Sruti Shiva and Wallace, {Douglas C.} and Weiss, {Robert G.} and Vernon, {Hilary J.} and Renee Wong and {Schwartz Longacre}, Lisa",

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doi = "10.1161/circulationaha.119.040551",

language = "English (US)",

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AU - Tian, Rong

AU - Colucci, Wilson S.

AU - Arany, Zoltan

AU - Bachschmid, Markus M.

AU - Ballinger, Scott W.

AU - Boudina, Sihem

AU - Bruce, James E.

AU - Busija, David W.

AU - Dikalov, Sergey

AU - Dorn, Gerald W.

AU - Galis, Zorina S.

AU - Gottlieb, Roberta A.

AU - Kelly, Daniel P.

AU - Kitsis, Richard N.

AU - Kohr, Mark J.

AU - Levy, Daniel

AU - Lewandowski, E. Douglas

AU - McClung, Joseph M.

AU - Mochly-Rosen, Daria

AU - O'Brien, Kevin D.

AU - O'Rourke, Brian

AU - Park, Joon Young

AU - Ping, Peipei

AU - Sack, Michael N.

AU - Sheu, Shey Shing

AU - Shi, Yang

AU - Shiva, Sruti

AU - Wallace, Douglas C.

AU - Weiss, Robert G.

AU - Vernon, Hilary J.

AU - Wong, Renee

AU - Schwartz Longacre, Lisa

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N2 - Mitochondria have emerged as a central factor in the pathogenesis and progression of heart failure, and other cardiovascular diseases, as well, but no therapies are available to treat mitochondrial dysfunction. The National Heart, Lung, and Blood Institute convened a group of leading experts in heart failure, cardiovascular diseases, and mitochondria research in August 2018. These experts reviewed the current state of science and identified key gaps and opportunities in basic, translational, and clinical research focusing on the potential of mitochondria-based therapeutic strategies in heart failure. The workshop provided short- and long-term recommendations for moving the field toward clinical strategies for the prevention and treatment of heart failure and cardiovascular diseases by using mitochondria-based approaches.

AB - Mitochondria have emerged as a central factor in the pathogenesis and progression of heart failure, and other cardiovascular diseases, as well, but no therapies are available to treat mitochondrial dysfunction. The National Heart, Lung, and Blood Institute convened a group of leading experts in heart failure, cardiovascular diseases, and mitochondria research in August 2018. These experts reviewed the current state of science and identified key gaps and opportunities in basic, translational, and clinical research focusing on the potential of mitochondria-based therapeutic strategies in heart failure. The workshop provided short- and long-term recommendations for moving the field toward clinical strategies for the prevention and treatment of heart failure and cardiovascular diseases by using mitochondria-based approaches.

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Unlocking the Secrets of Mitochondria in the Cardiovascular System: Path to a Cure in Heart Failure—A Report from the 2018 National Heart, Lung, and Blood Institute Workshop

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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