Unique opportunities for NMR methods in structural genomics

Gaetano T. Montelione; Cheryl Arrowsmith; Mark E. Girvin; Michael A. Kennedy; John L. Markley; Robert Powers; James H. Prestegard; Thomas Szyperski

doi:10.1007/s10969-009-9064-0

Unique opportunities for NMR methods in structural genomics

Gaetano T. Montelione
, Cheryl Arrowsmith
, Mark E. Girvin
, Michael A. Kennedy
, John L. Markley
, Robert Powers
, James H. Prestegard
, Thomas Szyperski

Biochemistry

Research output: Contribution to journal › Review article › peer-review

19 Scopus citations

Abstract

This Perspective, arising from a workshop held in July 2008 in Buffalo NY, provides an overview of the role NMR has played in the United States Protein Structure Initiative (PSI), and a vision of how NMR will contribute to the forthcoming PSI-Biology program. NMR has contributed in key ways to structure production by the PSI, and new methods have been developed which are impacting the broader protein NMR community.

Original language	English (US)
Pages (from-to)	101-106
Number of pages	6
Journal	Journal of Structural and Functional Genomics
Volume	10
Issue number	2
DOIs	https://doi.org/10.1007/s10969-009-9064-0
State	Published - Apr 2009

Keywords

Crystallography
Functional genomics
Future of structural genomics
NMR
NMR methods
Protein Structure Initiative (PSI)

ASJC Scopus subject areas

Structural Biology
Biochemistry
Genetics

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10.1007/s10969-009-9064-0

Cite this

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title = "Unique opportunities for NMR methods in structural genomics",

abstract = "This Perspective, arising from a workshop held in July 2008 in Buffalo NY, provides an overview of the role NMR has played in the United States Protein Structure Initiative (PSI), and a vision of how NMR will contribute to the forthcoming PSI-Biology program. NMR has contributed in key ways to structure production by the PSI, and new methods have been developed which are impacting the broader protein NMR community.",

keywords = "Crystallography, Functional genomics, Future of structural genomics, NMR, NMR methods, Protein Structure Initiative (PSI)",

author = "Montelione, \{Gaetano T.\} and Cheryl Arrowsmith and Girvin, \{Mark E.\} and Kennedy, \{Michael A.\} and Markley, \{John L.\} and Robert Powers and Prestegard, \{James H.\} and Thomas Szyperski",

note = "Funding Information: Acknowledgments We thank B. Mao and J. Everett for their assistance in statistical analyses. This work was supported by National Institutes of Health Grants U54-GM074958 (Northeast Structure Genomics Consortium), U54-GM75026 (New York Consortium on Membrane Protein Structure), U54-GM074901 (Center for Eukaryotic Structural Genomics), and P41-RR02301 (National Magnetic Resonance Facility at Madison).",

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doi = "10.1007/s10969-009-9064-0",

language = "English (US)",

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AU - Arrowsmith, Cheryl

AU - Girvin, Mark E.

AU - Kennedy, Michael A.

AU - Markley, John L.

AU - Powers, Robert

AU - Prestegard, James H.

AU - Szyperski, Thomas

N1 - Funding Information: Acknowledgments We thank B. Mao and J. Everett for their assistance in statistical analyses. This work was supported by National Institutes of Health Grants U54-GM074958 (Northeast Structure Genomics Consortium), U54-GM75026 (New York Consortium on Membrane Protein Structure), U54-GM074901 (Center for Eukaryotic Structural Genomics), and P41-RR02301 (National Magnetic Resonance Facility at Madison).

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AB - This Perspective, arising from a workshop held in July 2008 in Buffalo NY, provides an overview of the role NMR has played in the United States Protein Structure Initiative (PSI), and a vision of how NMR will contribute to the forthcoming PSI-Biology program. NMR has contributed in key ways to structure production by the PSI, and new methods have been developed which are impacting the broader protein NMR community.

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KW - Functional genomics

KW - Future of structural genomics

KW - NMR

KW - NMR methods

KW - Protein Structure Initiative (PSI)

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Unique opportunities for NMR methods in structural genomics

Abstract

Keywords

ASJC Scopus subject areas

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