Unilateral peri-substantia nigra catecholaminergic lesion and amygdala kindling

Bruce J. Albala; Solomon L. Moshé; Joseph F. Cubells; Nansie S. Sharpless; Maynard H. Makman

doi:10.1016/0006-8993(86)90500-7

Unilateral peri-substantia nigra catecholaminergic lesion and amygdala kindling

Bruce J. Albala, Solomon L. Moshé, Joseph F. Cubells, Nansie S. Sharpless, Maynard H. Makman

Neurology

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Recent evidence suggests that the substantia nigra (SN) may be involved in the modulation of kindled seizures in adult rats. In this report we investigated the role of the dopaminergic nigrostriatal pathway in mediating the SN effect on seizures by lesioning this pathway with unilateral infusions of 6-hydroxydopamine (6-OHDA) in the vicinity of the right SN with or without desmethylimipramine pretreatment. Our data suggest that the facilitation of amygdala kindling observed following 6-OHDA lesion in the vicinity of the ipsilateral SN is due to norepinephrine depletion of the ipsilateral forebrain. Selective destruction of the nigrostriatal dopaminergic neurons neither facilitates nor inhibits the development of amygdala-kindled convulsions in adult rats.

Original language	English (US)
Pages (from-to)	388-392
Number of pages	5
Journal	Brain research
Volume	370
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(86)90500-7
State	Published - Apr 9 1986

Keywords

amygdala
catecholamine
convulsion
epilepsy
kindling
rat
seizure
substantia nigra

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

Access to Document

10.1016/0006-8993(86)90500-7

Cite this

@article{e41771fe316643479ea698944ae3364a,

title = "Unilateral peri-substantia nigra catecholaminergic lesion and amygdala kindling",

abstract = "Recent evidence suggests that the substantia nigra (SN) may be involved in the modulation of kindled seizures in adult rats. In this report we investigated the role of the dopaminergic nigrostriatal pathway in mediating the SN effect on seizures by lesioning this pathway with unilateral infusions of 6-hydroxydopamine (6-OHDA) in the vicinity of the right SN with or without desmethylimipramine pretreatment. Our data suggest that the facilitation of amygdala kindling observed following 6-OHDA lesion in the vicinity of the ipsilateral SN is due to norepinephrine depletion of the ipsilateral forebrain. Selective destruction of the nigrostriatal dopaminergic neurons neither facilitates nor inhibits the development of amygdala-kindled convulsions in adult rats.",

keywords = "amygdala, catecholamine, convulsion, epilepsy, kindling, rat, seizure, substantia nigra",

author = "Albala, {Bruce J.} and Mosh{\'e}, {Solomon L.} and Cubells, {Joseph F.} and Sharpless, {Nansie S.} and Makman, {Maynard H.}",

year = "1986",

month = apr,

day = "9",

doi = "10.1016/0006-8993(86)90500-7",

language = "English (US)",

volume = "370",

pages = "388--392",

journal = "Brain research",

issn = "0006-8993",

publisher = "Elsevier",

number = "2",

}

TY - JOUR

T1 - Unilateral peri-substantia nigra catecholaminergic lesion and amygdala kindling

AU - Albala, Bruce J.

AU - Moshé, Solomon L.

AU - Cubells, Joseph F.

AU - Sharpless, Nansie S.

AU - Makman, Maynard H.

PY - 1986/4/9

Y1 - 1986/4/9

N2 - Recent evidence suggests that the substantia nigra (SN) may be involved in the modulation of kindled seizures in adult rats. In this report we investigated the role of the dopaminergic nigrostriatal pathway in mediating the SN effect on seizures by lesioning this pathway with unilateral infusions of 6-hydroxydopamine (6-OHDA) in the vicinity of the right SN with or without desmethylimipramine pretreatment. Our data suggest that the facilitation of amygdala kindling observed following 6-OHDA lesion in the vicinity of the ipsilateral SN is due to norepinephrine depletion of the ipsilateral forebrain. Selective destruction of the nigrostriatal dopaminergic neurons neither facilitates nor inhibits the development of amygdala-kindled convulsions in adult rats.

AB - Recent evidence suggests that the substantia nigra (SN) may be involved in the modulation of kindled seizures in adult rats. In this report we investigated the role of the dopaminergic nigrostriatal pathway in mediating the SN effect on seizures by lesioning this pathway with unilateral infusions of 6-hydroxydopamine (6-OHDA) in the vicinity of the right SN with or without desmethylimipramine pretreatment. Our data suggest that the facilitation of amygdala kindling observed following 6-OHDA lesion in the vicinity of the ipsilateral SN is due to norepinephrine depletion of the ipsilateral forebrain. Selective destruction of the nigrostriatal dopaminergic neurons neither facilitates nor inhibits the development of amygdala-kindled convulsions in adult rats.

KW - amygdala

KW - catecholamine

KW - convulsion

KW - epilepsy

KW - kindling

KW - rat

KW - seizure

KW - substantia nigra

UR - http://www.scopus.com/inward/record.url?scp=0022547422&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022547422&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(86)90500-7

DO - 10.1016/0006-8993(86)90500-7

M3 - Article

C2 - 3085869

AN - SCOPUS:0022547422

SN - 0006-8993

VL - 370

SP - 388

EP - 392

JO - Brain research

JF - Brain research

IS - 2

ER -

Unilateral peri-substantia nigra catecholaminergic lesion and amygdala kindling

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this