Unexpected case of cryptococcal meningoencephalitis in a patient with long-standing well-controlled HIV infection

Hyun ah Yoon; Paul F. Riska; Ruchika Jain; Cariane Morales; Liise anne Pirofski

doi:10.1016/j.mmcr.2021.01.003

Unexpected case of cryptococcal meningoencephalitis in a patient with long-standing well-controlled HIV infection

Hyun ah Yoon, Paul F. Riska, Ruchika Jain, Cariane Morales, Liise anne Pirofski

Medicine

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Cryptococcal meningoencephalitis (CM) classically occurs in individuals with advanced HIV infection, solid organ transplants, or other immunocompromising conditions. We report a case of fatal CM in a 78-year-old woman with well-controlled HIV infection who had delayed diagnosis, persistently elevated intracranial pressure and pleocytosis of the cerebrospinal fluid. Initial suspicion for CM was low due to her relatively high CD4⁺ T cell counts, which likely contributed to greater inflammation.

Original language	English (US)
Pages (from-to)	14-16
Number of pages	3
Journal	Medical Mycology Case Reports
Volume	32
DOIs	https://doi.org/10.1016/j.mmcr.2021.01.003
State	Published - Jun 2021

Keywords

Cryptococcal meningoencephalitis
Cryptococcosis
HIV infection
Host immunity
Inflammatory response

ASJC Scopus subject areas

Microbiology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.mmcr.2021.01.003

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@article{2379ff20e1a0408fae19115a97951251,

title = "Unexpected case of cryptococcal meningoencephalitis in a patient with long-standing well-controlled HIV infection",

abstract = "Cryptococcal meningoencephalitis (CM) classically occurs in individuals with advanced HIV infection, solid organ transplants, or other immunocompromising conditions. We report a case of fatal CM in a 78-year-old woman with well-controlled HIV infection who had delayed diagnosis, persistently elevated intracranial pressure and pleocytosis of the cerebrospinal fluid. Initial suspicion for CM was low due to her relatively high CD4+ T cell counts, which likely contributed to greater inflammation.",

keywords = "Cryptococcal meningoencephalitis, Cryptococcosis, HIV infection, Host immunity, Inflammatory response",

author = "Yoon, {Hyun ah} and Riska, {Paul F.} and Ruchika Jain and Cariane Morales and Pirofski, {Liise anne}",

note = "Publisher Copyright: {\textcopyright} 2021 The Authors",

year = "2021",

month = jun,

doi = "10.1016/j.mmcr.2021.01.003",

language = "English (US)",

volume = "32",

pages = "14--16",

journal = "Medical Mycology Case Reports",

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TY - JOUR

T1 - Unexpected case of cryptococcal meningoencephalitis in a patient with long-standing well-controlled HIV infection

AU - Yoon, Hyun ah

AU - Riska, Paul F.

AU - Jain, Ruchika

AU - Morales, Cariane

AU - Pirofski, Liise anne

PY - 2021/6

Y1 - 2021/6

N2 - Cryptococcal meningoencephalitis (CM) classically occurs in individuals with advanced HIV infection, solid organ transplants, or other immunocompromising conditions. We report a case of fatal CM in a 78-year-old woman with well-controlled HIV infection who had delayed diagnosis, persistently elevated intracranial pressure and pleocytosis of the cerebrospinal fluid. Initial suspicion for CM was low due to her relatively high CD4+ T cell counts, which likely contributed to greater inflammation.

AB - Cryptococcal meningoencephalitis (CM) classically occurs in individuals with advanced HIV infection, solid organ transplants, or other immunocompromising conditions. We report a case of fatal CM in a 78-year-old woman with well-controlled HIV infection who had delayed diagnosis, persistently elevated intracranial pressure and pleocytosis of the cerebrospinal fluid. Initial suspicion for CM was low due to her relatively high CD4+ T cell counts, which likely contributed to greater inflammation.

KW - Cryptococcal meningoencephalitis

KW - Cryptococcosis

KW - HIV infection

KW - Host immunity

KW - Inflammatory response

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U2 - 10.1016/j.mmcr.2021.01.003

DO - 10.1016/j.mmcr.2021.01.003

M3 - Article

AN - SCOPUS:85099940697

SN - 2211-7539

VL - 32

SP - 14

EP - 16

JO - Medical Mycology Case Reports

JF - Medical Mycology Case Reports

ER -

Unexpected case of cryptococcal meningoencephalitis in a patient with long-standing well-controlled HIV infection

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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