Understanding unmet needs in the older acute myeloid leukemia (AML) patient

Pablo Loarte, Irina Dashkova, Leanne Tortez, Anna Dashkova, Andrzej Kozikowski, Ramy Ibrahim, Renee Pekmezaris

Research output: Contribution to journalReview articlepeer-review


Introduction: Acute Myeloid Leukemia (AML) is a rare form of cancer characterized by the infiltration of abnormal white blood cells that accumulate in the bone marrow at a rapid rate. AML has an overall incidence of 4 per 100,000 persons and accounted for over 10,000 deaths within the United States in 2015 [1]. Indeed, AML also represents a disease typically associated with the elderly, as the median age of diagnosis for AML is around 72 years old [2]. Advances: Over the past decades we have seen major advances in terms of understanding AML’s biology and prognosis, but some questions still remain unanswered, particularly for the elderly population. This gap in our understanding of AML translates into unmet needs for this population. Conclusion: The current paper seeks to describe these specific needs and their associated barriers related to treatment, prognostic factors and relapse, health-related quality of life, disease costs, and palliative care support. Acquiring a better understanding of AML for elderly patients can lead to improved therapy options and quality-of-life for this population.

Original languageEnglish (US)
Pages (from-to)246-252
Number of pages7
JournalCurrent Cancer Therapy Reviews
Issue number4
StatePublished - Dec 1 2016
Externally publishedYes


  • Acute myeloid leukemia
  • Age
  • Chemotherapy
  • Older
  • Treatment
  • Unmet needs

ASJC Scopus subject areas

  • Molecular Medicine
  • Oncology
  • Cancer Research


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