TY - JOUR
T1 - Understanding FLT3 Inhibitor Resistance to Rationalize Combinatorial AML Therapies
AU - Shastri, Aditi
AU - Gonzalez-Lugo, Jesus
AU - Verma, Amit
N1 - Publisher Copyright:
©2020 American Association for Cancer Research.
PY - 2021/3/1
Y1 - 2021/3/1
N2 - Summary: Patients treated with Fms-like tyrosine kinase 3 (FLT3) inhibitor–based acute myeloid leukemia therapies nearly always develop resistance. In this issue, Alotaibi and colleagues describe the patterns of mutations that emerge upon relapse after FLT3 inhibitor therapy after initial response, as well as in treatment-refractory disease in a single-institution study; the findings offer insights for sequential therapies targeting the dominant clone at the time of relapse.
AB - Summary: Patients treated with Fms-like tyrosine kinase 3 (FLT3) inhibitor–based acute myeloid leukemia therapies nearly always develop resistance. In this issue, Alotaibi and colleagues describe the patterns of mutations that emerge upon relapse after FLT3 inhibitor therapy after initial response, as well as in treatment-refractory disease in a single-institution study; the findings offer insights for sequential therapies targeting the dominant clone at the time of relapse.
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U2 - 10.1158/2643-3230.BCD-20-0210
DO - 10.1158/2643-3230.BCD-20-0210
M3 - Review article
C2 - 34661152
AN - SCOPUS:85137762526
SN - 2643-3230
VL - 2
SP - 113
EP - 115
JO - Blood cancer discovery
JF - Blood cancer discovery
IS - 2
ER -