Ultrastructure of cerebellar hemangioblastoma - Some new observations on the stromal cells

T. Shimura, A. Hirano, J. F. Llena

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Five cases of hemangioblastoma were studied by electron microscopy with particular attention to the stromal cells and their surrounding structures. Most of the stromal cells of the tumor had abundant clear cytoplasm containing rough endoplasmic reticulum, mitochondria, scattered fibrils, and large lipid inclusions. They were usually aggregated without intervening cells. In the perivascular areas, their sufaces facing the perivascular collagen were surrounded by basal lamina. Their apposed cell membranes had occasional adhesive devices. Occasional, long, apparently cylindrical processes of the stromal cell cytoplasm were observed in some cases. These processes contained intermediate filaments of undetermined nature and microtubules. In the border zone between the tumor and the surrounding brain, the stromal cells were occasionally surrounded by narrow sheets of dark cell processes containing fibrils and glycogen granules, consistent with astrocytic processes. Altered neuronal elements were also observed inthis area.

Original languageEnglish (US)
Pages (from-to)6-12
Number of pages7
JournalActa neuropathologica
Issue number1-2
StatePublished - Mar 1985
Externally publishedYes


  • Adjacent brain
  • Cerebellar hemangioblastoma
  • Cytoplasmic process
  • Stromal cells
  • Ultrastructure

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience


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