TY - JOUR
T1 - Type-specific prevalence of human papillomavirus DNA among Jamaican colposcopy patients
AU - Rattray, Carole
AU - Strickler, Howard D.
AU - Escoffery, Carlos
AU - Cranston, Beverly
AU - Brown, Claudette
AU - Manns, Angela
AU - Schiffman, Mark H.
AU - Palefsky, Joel M.
AU - Hanchard, Barrie
AU - Blattner, William A.
PY - 1996
Y1 - 1996
N2 - Human papillomavirus (HPV) types differ in their association with cervical cancer. Therefore, the types of HPV in precancerous lesions are important. In many regions with high cancer incidence, the HPV types in precancerous lesions have not been well studied. In Jamaica, a country that has high cervical cancer incidence, 174 colposcopy patients were tested for HPV DNA using polymerase chain reaction. HPV DNA detection was strongly related to presence and grade of cervical neoplasia (P < .001). Furthermore, severe neoplastic change was most highly associated with HPV DNA types also considered high-risk for severe neoplasia in other populations. HPV-45 DNA, a high-risk type uncommon in most previously tested countries, was detected in 12% of patients who had neoplasia. Thus, cervical neoplasia in Jamaica, as elsewhere, is linked to HPV. The high prevalence of HPV-45 DNA was notable, and its relation to high cervical cancer incidence in Jamaica must be assessed.
AB - Human papillomavirus (HPV) types differ in their association with cervical cancer. Therefore, the types of HPV in precancerous lesions are important. In many regions with high cancer incidence, the HPV types in precancerous lesions have not been well studied. In Jamaica, a country that has high cervical cancer incidence, 174 colposcopy patients were tested for HPV DNA using polymerase chain reaction. HPV DNA detection was strongly related to presence and grade of cervical neoplasia (P < .001). Furthermore, severe neoplastic change was most highly associated with HPV DNA types also considered high-risk for severe neoplasia in other populations. HPV-45 DNA, a high-risk type uncommon in most previously tested countries, was detected in 12% of patients who had neoplasia. Thus, cervical neoplasia in Jamaica, as elsewhere, is linked to HPV. The high prevalence of HPV-45 DNA was notable, and its relation to high cervical cancer incidence in Jamaica must be assessed.
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U2 - 10.1093/infdis/173.3.718
DO - 10.1093/infdis/173.3.718
M3 - Article
C2 - 8627038
AN - SCOPUS:19144370921
SN - 0022-1899
VL - 173
SP - 718
EP - 721
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 3
ER -
