Type 1 HERV-K genome is spliced into subgenomic transcripts in the human breast tumor cell line T47D

Polly R. Etkind; Kathryn Lumb; Juan Du; Janis Racevskis

doi:10.1006/viro.1997.8670

Type 1 HERV-K genome is spliced into subgenomic transcripts in the human breast tumor cell line T47D

Polly R. Etkind
, Kathryn Lumb
, Juan Du
, Janis Racevskis

Oncology

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Two types of HERV-K genomes exist which differ in the absence (type 1) or the presence (type 2) of a sequence of 292 nucleotides between the putative pol and any genes. Previously published results from teratocarcinoma cell studies had firmly concluded that the type 1 HERV-K genome was defective in splicing and that only the nondeleted type 2 HERV-K genome containing the 292-nucleotide sequence was capable of being spliced. We now show that in the T47D human breast tumor cell line it is the type 1 HERV-K genome, and not the type 2, which is spliced to subgenomic transcripts.

Original language	English (US)
Pages (from-to)	304-308
Number of pages	5
Journal	Virology
Volume	234
Issue number	2
DOIs	https://doi.org/10.1006/viro.1997.8670
State	Published - Aug 4 1997

ASJC Scopus subject areas

Virology

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10.1006/viro.1997.8670

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title = "Type 1 HERV-K genome is spliced into subgenomic transcripts in the human breast tumor cell line T47D",

abstract = "Two types of HERV-K genomes exist which differ in the absence (type 1) or the presence (type 2) of a sequence of 292 nucleotides between the putative pol and any genes. Previously published results from teratocarcinoma cell studies had firmly concluded that the type 1 HERV-K genome was defective in splicing and that only the nondeleted type 2 HERV-K genome containing the 292-nucleotide sequence was capable of being spliced. We now show that in the T47D human breast tumor cell line it is the type 1 HERV-K genome, and not the type 2, which is spliced to subgenomic transcripts.",

author = "Etkind, \{Polly R.\} and Kathryn Lumb and Juan Du and Janis Racevskis",

note = "Funding Information: We thank Michelle Houston for her invaluable help with the Phos-phorImager analysis of our hybridization data. This work was sponsored in part by Public Service Core Grant 133330 and Planning Grant for Breast Cancer Research Programs R21 CA66183 from the National Cancer Institute to the Albert Einstein Cancer Center. The contents of this publication are solely the responsibility of the authors and do not necessarily represent the official views of the National Cancer Institute.",

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AU - Etkind, Polly R.

AU - Lumb, Kathryn

AU - Du, Juan

AU - Racevskis, Janis

N1 - Funding Information: We thank Michelle Houston for her invaluable help with the Phos-phorImager analysis of our hybridization data. This work was sponsored in part by Public Service Core Grant 133330 and Planning Grant for Breast Cancer Research Programs R21 CA66183 from the National Cancer Institute to the Albert Einstein Cancer Center. The contents of this publication are solely the responsibility of the authors and do not necessarily represent the official views of the National Cancer Institute.

PY - 1997/8/4

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N2 - Two types of HERV-K genomes exist which differ in the absence (type 1) or the presence (type 2) of a sequence of 292 nucleotides between the putative pol and any genes. Previously published results from teratocarcinoma cell studies had firmly concluded that the type 1 HERV-K genome was defective in splicing and that only the nondeleted type 2 HERV-K genome containing the 292-nucleotide sequence was capable of being spliced. We now show that in the T47D human breast tumor cell line it is the type 1 HERV-K genome, and not the type 2, which is spliced to subgenomic transcripts.

AB - Two types of HERV-K genomes exist which differ in the absence (type 1) or the presence (type 2) of a sequence of 292 nucleotides between the putative pol and any genes. Previously published results from teratocarcinoma cell studies had firmly concluded that the type 1 HERV-K genome was defective in splicing and that only the nondeleted type 2 HERV-K genome containing the 292-nucleotide sequence was capable of being spliced. We now show that in the T47D human breast tumor cell line it is the type 1 HERV-K genome, and not the type 2, which is spliced to subgenomic transcripts.

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Type 1 HERV-K genome is spliced into subgenomic transcripts in the human breast tumor cell line T47D

Abstract

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