Two-year outcomes of surgical treatment of moderate ischemic mitral regurgitation

Robert E. Michler, Peter K. Smith, Michael K. Parides, Gorav Ailawadi, Vinod Thourani, Alan J. Moskowitz, Michael A. Acker, Judy W. Hung, Helena L. Chang, Louis P. Perrault, A. Marc Gillinov, Michael Argenziano, Emilia Bagiella, Jessica R. Overbey, Ellen G. Moquete, Lopa N. Gupta, Marissa A. Miller, Wendy C. Taddei-Peters, Neal Jeffries, Richard D. WeiselEric A. Rose, James S. Gammie, Joseph J. DeRose, John D. Puskas, François Dagenais, Sandra G. Burks, Ismail El-Hamamsy, Carmelo A. Milano, Pavan Atluri, Pierre Voisine, Patrick T. O'Gara, Annetine C. Gelijns

Research output: Contribution to journalArticlepeer-review

395 Scopus citations


BACKGROUND: In a trial comparing coronary-artery bypass grafting (CABG) alone with CABG plus mitral-valve repair in patients with moderate ischemic mitral regurgitation, we found no significant difference in the left ventricular end-systolic volume index (LVESVI) or survival after 1 year. Concomitant mitral-valve repair was associated with a reduced prevalence of moderate or severe mitral regurgitation, but patients had more adverse events. We now report 2-year outcomes. METHODS: We randomly assigned 301 patients to undergo either CABG alone or the combined procedure. Patients were followed for 2 years for clinical and echocardiographic outcomes. RESULTS: At 2 years, the mean (±SD) LVESVI was 41.2±20.0 ml per square meter of bodysurface area in the CABG-alone group and 43.2±20.6 ml per square meter in the combined-procedure group (mean improvement over baseline, -14.1 ml per square meter and -14.6 ml per square meter, respectively). The rate of death was 10.6% in the CABG-alone group and 10.0% in the combined-procedure group (hazard ratio in the combined-procedure group, 0.90; 95% confidence interval, 0.45 to 1.83; P = 0.78). There was no significant between-group difference in the rank-based assessment of the LVESVI (including death) at 2 years (z score, 0.38; P = 0.71). The 2-year rate of moderate or severe residual mitral regurgitation was higher in the CABG-alone group than in the combined-procedure group (32.3% vs. 11.2%, P<0.001). Overall rates of hospital readmission and serious adverse events were similar in the two groups, but neurologic events and supraventricular arrhythmias remained more frequent in the combined-procedure group. CONCLUSIONS: In patients with moderate ischemic mitral regurgitation undergoing CABG, the addition of mitral-valve repair did not lead to significant differences in left ventricular reverse remodeling at 2 years. Mitral-valve repair provided a more durable correction of mitral regurgitation but did not significantly improve survival or reduce overall adverse events or readmissions and was associated with an early hazard of increased neurologic events and supraventricular arrhythmias.

Original languageEnglish (US)
Pages (from-to)1932-1941
Number of pages10
JournalNew England Journal of Medicine
Issue number20
StatePublished - May 19 2016

ASJC Scopus subject areas

  • General Medicine


Dive into the research topics of 'Two-year outcomes of surgical treatment of moderate ischemic mitral regurgitation'. Together they form a unique fingerprint.

Cite this