@article{7b0eed82e73246e0b8fce5b03550e5b4,
title = "Tryptophan Metabolism as a Pharmacological Target",
abstract = "L-Tryptophan is an essential amino acid required for protein synthesis. It undergoes an extensive and complex metabolism along several pathways, resulting in many bioactive molecules acting in various organs through different action mechanisms. Enzymes involved in its metabolism, metabolites themselves, or their receptors, represent potential therapeutic targets, which are the subject of dynamic research. Disruptions in L-tryptophan metabolism are reported in several neurological, metabolic, psychiatric, and intestinal disorders, paving the way to develop drugs to target it. This review will briefly describe L-tryptophan metabolism and present and discuss the most recent pharmacological developments targeting it.",
keywords = "AhR, IDO, kynurenine, serotonin, therapeutics, tryptophan",
author = "Morgane Modoux and Nathalie Rolhion and Sridhar Mani and Harry Sokol",
note = "Funding Information: Harry Sokol received funding from the European Research Council (ERC) under the European Union{\textquoteright}s Horizon 2020 Research and Innovation Program ( ERC-2016-StG-71577 ). The Peer-Reviewed Medical Research Program also supported this work – Investigator-Initiated Research Award under Award No. W81XWH-17-1-0479; National Institutes of Health (NIH) grants ( ES030197 ; CA 222469 ). Funding Information: Harry Sokol received funding from the European Research Council (ERC) under the European Union's Horizon 2020 Research and Innovation Program (ERC-2016-StG-71577). The Peer-Reviewed Medical Research Program also supported this work ? Investigator-Initiated Research Award under Award No. W81XWH-17-1-0479; National Institutes of Health (NIH) grants (ES030197; CA 222469). H.S. received unrestricted study grants from Danone, Biocodex, and Enterome; board membership, consultancy, or lecture fees from Carenity, Abbvie, Astellas, Danone, Ferring, Mayoly Spindler, MSD, Novartis, Roche, Tillots, Enterome, Maat, BiomX, Biose, Novartis, and Takeda; and is a co-founder of Exeliom bioscience. Publisher Copyright: {\textcopyright} 2020 The Authors",
year = "2021",
month = jan,
doi = "10.1016/j.tips.2020.11.006",
language = "English (US)",
volume = "42",
pages = "60--73",
journal = "Trends in Pharmacological Sciences",
issn = "0165-6147",
publisher = "Elsevier Limited",
number = "1",
}