Topical Ultraviolet Light-Absorbing Chromophore Protects Against Experimental Photokeratitis

J. Brent Oldenburg, David C. Gritz, Peter J. McDonnell

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Ultraviolet radiation may play a causative role in a number of human ocular and dermatologic conditions; reduction of environmental UV light exposure may decrease their incidence. We investigated the effects of two different UV light-absorbing chromophores, octyl methoxycinnamate (Parsol-MCX) and butyl methoxydibenzoylmethane (Parsol-1789) on corneal UV light transmittance, and evaluated topically applied Parsol-MCX for its protective effect against experimental UV light-induced keratitis in New Zealand white rabbits. Both Parsol-1789 (UV-A light absorber) and Parsol-MCX (UV-B light absorber) are well tolerated by New Zealand white rabbit eyes. Pretreatment with a single drop of Parsol-MCX reproducibly protected against UV light-induced keratitis, apparently by absorbing greater than 75% of UV-B (peak wavelength, 308 nm) irradiation.

Original languageEnglish (US)
Pages (from-to)1142-1144
Number of pages3
JournalArchives of Ophthalmology
Issue number8
StatePublished - Aug 1990
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology


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