To the nucleus with proteomics

Bryen A. Jordan; Edward B. Ziff

doi:10.1007/978-0-387-73609-9_2

To the nucleus with proteomics

Bryen A. Jordan, Edward B. Ziff

Research output: Chapter in Book/Report/Conference proceeding › Chapter

3 Scopus citations

Abstract

In this chapter we review proteomic studies performed on purified postsynaptic density (PSD) fractions and analyze what their results reveal about nuclear signaling. Overall, these studies show that PSDs are similar to the cytoplasmic protein complexes found at other intercellular junctions. We find that PSDs contain numerous calmodulin (CAM)-associated transcriptional coactivators, nucleocytoplasmic shuttling proteins that bind RNA and potential splicing factors. Moreover, in conjunction with bioinformatics, we identify novel nucleocytoplasmic shuttling proteins at synapses. These results strongly suggest that control of the spatial distribution of synapse-associated nuclear factors regulates nuclear function.

Original language	English (US)
Title of host publication	Transcriptional Regulation by Neuronal Activity
Subtitle of host publication	To the Nucleus and Back
Publisher	Springer US
Pages	27-50
Number of pages	24
ISBN (Electronic)	9780387736099
ISBN (Print)	9780387736082
DOIs	https://doi.org/10.1007/978-0-387-73609-9_2
State	Published - 2008
Externally published	Yes

ASJC Scopus subject areas

General Medicine
General Neuroscience

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10.1007/978-0-387-73609-9_2

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title = "To the nucleus with proteomics",

abstract = "In this chapter we review proteomic studies performed on purified postsynaptic density (PSD) fractions and analyze what their results reveal about nuclear signaling. Overall, these studies show that PSDs are similar to the cytoplasmic protein complexes found at other intercellular junctions. We find that PSDs contain numerous calmodulin (CAM)-associated transcriptional coactivators, nucleocytoplasmic shuttling proteins that bind RNA and potential splicing factors. Moreover, in conjunction with bioinformatics, we identify novel nucleocytoplasmic shuttling proteins at synapses. These results strongly suggest that control of the spatial distribution of synapse-associated nuclear factors regulates nuclear function.",

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AU - Ziff, Edward B.

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AB - In this chapter we review proteomic studies performed on purified postsynaptic density (PSD) fractions and analyze what their results reveal about nuclear signaling. Overall, these studies show that PSDs are similar to the cytoplasmic protein complexes found at other intercellular junctions. We find that PSDs contain numerous calmodulin (CAM)-associated transcriptional coactivators, nucleocytoplasmic shuttling proteins that bind RNA and potential splicing factors. Moreover, in conjunction with bioinformatics, we identify novel nucleocytoplasmic shuttling proteins at synapses. These results strongly suggest that control of the spatial distribution of synapse-associated nuclear factors regulates nuclear function.

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BT - Transcriptional Regulation by Neuronal Activity

PB - Springer US

ER -

To the nucleus with proteomics

Abstract

ASJC Scopus subject areas

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