To the nucleus with proteomics

Bryen A. Jordan, Edward B. Ziff

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations


In this chapter we review proteomic studies performed on purified postsynaptic density (PSD) fractions and analyze what their results reveal about nuclear signaling. Overall, these studies show that PSDs are similar to the cytoplasmic protein complexes found at other intercellular junctions. We find that PSDs contain numerous calmodulin (CAM)-associated transcriptional coactivators, nucleocytoplasmic shuttling proteins that bind RNA and potential splicing factors. Moreover, in conjunction with bioinformatics, we identify novel nucleocytoplasmic shuttling proteins at synapses. These results strongly suggest that control of the spatial distribution of synapse-associated nuclear factors regulates nuclear function.

Original languageEnglish (US)
Title of host publicationTranscriptional Regulation by Neuronal Activity
Subtitle of host publicationTo the Nucleus and Back
PublisherSpringer US
Number of pages24
ISBN (Electronic)9780387736099
ISBN (Print)9780387736082
StatePublished - Jan 1 2008
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)


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