Thymic Hypoplasia Associated With Isotretinoin Embryopathy

Morris Cohen, Arye Rubinstein, John K. Li, Gerald Nathenson

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


A newborn had isotretinoin embryopathy, including thymic hypoplasia. Evaluation of her immune functions demonstrated progressive attrition of T cells over the nine weeks until her death due to pneumonia. These studies strongly suggest an insult by isotretinoin to the immune system. Immune abnormalities may predispose infants with isotretinoin embryopathy to infection and contribute to their high mortality.

Original languageEnglish (US)
Pages (from-to)263-266
Number of pages4
JournalAmerican Journal of Diseases of Children
Issue number3
StatePublished - Mar 1987

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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