Abstract
Theophylline, a methylxanthine commonly used as a treatment for asthma, has been shown to induce apoptosis in chronic lymphocytic leukemia (CLL) cells both in vitro and in vivo. We have treated three advanced CLL patients with theophylline, and seen responses in two. The clinical courses of the responders are presented, and the literature concerning theophylline as therapy for CLL is reviewed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 69-71 |
| Number of pages | 3 |
| Journal | Medical Oncology and Tumor Pharmacotherapy |
| Volume | 16 |
| Issue number | 1 |
| DOIs | |
| State | Published - Apr 1999 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Apoptosis
- Chronic lymphocytic leukemia
- Cyclic adenosine monophosphate
- Methylxanthine
- Theophylline
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research
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