Therapeutic efficacy of theophylline in chronic lymphocytic leukemia

Della Makower, Ummekalsoom Malik, Yelena Novik, Peter H. Wiernik

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Theophylline, a methylxanthine commonly used as a treatment for asthma, has been shown to induce apoptosis in chronic lymphocytic leukemia (CLL) cells both in vitro and in vivo. We have treated three advanced CLL patients with theophylline, and seen responses in two. The clinical courses of the responders are presented, and the literature concerning theophylline as therapy for CLL is reviewed.

Original languageEnglish (US)
Pages (from-to)69-71
Number of pages3
JournalMedical Oncology
Issue number1
StatePublished - Apr 1 1999


  • Apoptosis
  • Chronic lymphocytic leukemia
  • Cyclic adenosine monophosphate
  • Methylxanthine
  • Theophylline

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research


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