Therapeutic effect of a novel anilidoquinoline derivative, 2-(2-methyl-quinoline-4ylamino)-N-(2-chlorophenyl)-acetamide, in Japanese encephalitis: correlation with in vitro neuroprotection

Joydeep Ghosh; Vivek Swarup; Amit Saxena; Sulagna Das; Abhijit Hazra; Priyankar Paira; Sukdeb Banerjee; Nirup B. Mondal; Anirban Basu

doi:10.1016/j.ijantimicag.2008.05.001

Therapeutic effect of a novel anilidoquinoline derivative, 2-(2-methyl-quinoline-4ylamino)-N-(2-chlorophenyl)-acetamide, in Japanese encephalitis: correlation with in vitro neuroprotection

Joydeep Ghosh
, Vivek Swarup
, Amit Saxena
, Sulagna Das
, Abhijit Hazra
, Priyankar Paira
, Sukdeb Banerjee
, Nirup B. Mondal
, Anirban Basu

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

2-(2-Methyl-quinoline-4ylamino)-N-(2-chlorophenyl)-acetamide, a novel anilidoquinoline derivative, was synthesised and evaluated for its therapeutic efficacy in treating Japanese encephalitis. The compound showed significant antiviral and antiapoptotic effects in vitro. Significant decreases in viral load (P < 0.01) combined with an increase in survival was observed in Japanese encephalitis virus-infected mice treated with 2-(2-methyl-quinoline-4ylamino)-N-(2-chlorophenyl)-acetamide.

Original language	English (US)
Pages (from-to)	349-354
Number of pages	6
Journal	International Journal of Antimicrobial Agents
Volume	32
Issue number	4
DOIs	https://doi.org/10.1016/j.ijantimicag.2008.05.001
State	Published - Oct 2008
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Anilidoquinoline
Apoptosis
Japanese encephalitis virus
Neuron
TUNEL

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases
Pharmacology (medical)

Access to Document

10.1016/j.ijantimicag.2008.05.001

Cite this

Ghosh, J., Swarup, V., Saxena, A., Das, S., Hazra, A., Paira, P., Banerjee, S., Mondal, N. B., & Basu, A. (2008). Therapeutic effect of a novel anilidoquinoline derivative, 2-(2-methyl-quinoline-4ylamino)-N-(2-chlorophenyl)-acetamide, in Japanese encephalitis: correlation with in vitro neuroprotection. International Journal of Antimicrobial Agents, 32(4), 349-354. https://doi.org/10.1016/j.ijantimicag.2008.05.001

Therapeutic effect of a novel anilidoquinoline derivative, 2-(2-methyl-quinoline-4ylamino)-N-(2-chlorophenyl)-acetamide, in Japanese encephalitis: correlation with in vitro neuroprotection. / Ghosh, Joydeep; Swarup, Vivek; Saxena, Amit et al.
In: International Journal of Antimicrobial Agents, Vol. 32, No. 4, 10.2008, p. 349-354.

Research output: Contribution to journal › Article › peer-review

Ghosh, J, Swarup, V, Saxena, A, Das, S, Hazra, A, Paira, P, Banerjee, S, Mondal, NB & Basu, A 2008, 'Therapeutic effect of a novel anilidoquinoline derivative, 2-(2-methyl-quinoline-4ylamino)-N-(2-chlorophenyl)-acetamide, in Japanese encephalitis: correlation with in vitro neuroprotection', International Journal of Antimicrobial Agents, vol. 32, no. 4, pp. 349-354. https://doi.org/10.1016/j.ijantimicag.2008.05.001

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title = "Therapeutic effect of a novel anilidoquinoline derivative, 2-(2-methyl-quinoline-4ylamino)-N-(2-chlorophenyl)-acetamide, in Japanese encephalitis: correlation with in vitro neuroprotection",

abstract = "2-(2-Methyl-quinoline-4ylamino)-N-(2-chlorophenyl)-acetamide, a novel anilidoquinoline derivative, was synthesised and evaluated for its therapeutic efficacy in treating Japanese encephalitis. The compound showed significant antiviral and antiapoptotic effects in vitro. Significant decreases in viral load (P < 0.01) combined with an increase in survival was observed in Japanese encephalitis virus-infected mice treated with 2-(2-methyl-quinoline-4ylamino)-N-(2-chlorophenyl)-acetamide.",

keywords = "Anilidoquinoline, Apoptosis, Japanese encephalitis virus, Neuron, TUNEL",

author = "Joydeep Ghosh and Vivek Swarup and Amit Saxena and Sulagna Das and Abhijit Hazra and Priyankar Paira and Sukdeb Banerjee and Mondal, \{Nirup B.\} and Anirban Basu",

note = "Funding Information: Funding: This work was supported by grant nos. BT/PR/5799/MED/14/698/2005 and BT/PR/8682/MED/14/1275/2007 from the Department of Biotechnology, Government of India, to AB. Copyright: Copyright 2009 Elsevier B.V., All rights reserved.",

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doi = "10.1016/j.ijantimicag.2008.05.001",

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AU - Das, Sulagna

AU - Hazra, Abhijit

AU - Paira, Priyankar

AU - Banerjee, Sukdeb

AU - Mondal, Nirup B.

AU - Basu, Anirban

N1 - Funding Information: Funding: This work was supported by grant nos. BT/PR/5799/MED/14/698/2005 and BT/PR/8682/MED/14/1275/2007 from the Department of Biotechnology, Government of India, to AB. Copyright: Copyright 2009 Elsevier B.V., All rights reserved.

PY - 2008/10

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KW - Anilidoquinoline

KW - Apoptosis

KW - Japanese encephalitis virus

KW - Neuron

KW - TUNEL

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Therapeutic effect of a novel anilidoquinoline derivative, 2-(2-methyl-quinoline-4ylamino)-N-(2-chlorophenyl)-acetamide, in Japanese encephalitis: correlation with in vitro neuroprotection

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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