TY - JOUR
T1 - The use of levo-carnitine in children with renal disease
T2 - A review and a call for future studies
AU - Belay, Brook
AU - Esteban-Cruciani, Nora
AU - Walsh, Christine A.
AU - Kaskel, Frederick J.
PY - 2006/3
Y1 - 2006/3
N2 - Carnitine is an amino acid derivative that has a key role in the regulation of fatty acid metabolism and ATP formation. Carnitine deficiency has been described in various conditions, including chronic kidney disease (CKD) and end stage renal disease (ESRD). The deficiency of this micronutrient is postulated to lead to adverse effects across multiple organ systems. There is a paucity of information on carnitine deficiency and its effects in the pediatric CKD and ESRD populations. Currently, there is no evidence supporting the routine use of carnitine supplementation in children with ESRD. In this article, we review the pathophysiology, pharmacokinetics and the potential effects of levo-carnitine supplementation with a focus on the pediatric CKD and ESRD populations. Finally, potential future directions of research are discussed.
AB - Carnitine is an amino acid derivative that has a key role in the regulation of fatty acid metabolism and ATP formation. Carnitine deficiency has been described in various conditions, including chronic kidney disease (CKD) and end stage renal disease (ESRD). The deficiency of this micronutrient is postulated to lead to adverse effects across multiple organ systems. There is a paucity of information on carnitine deficiency and its effects in the pediatric CKD and ESRD populations. Currently, there is no evidence supporting the routine use of carnitine supplementation in children with ESRD. In this article, we review the pathophysiology, pharmacokinetics and the potential effects of levo-carnitine supplementation with a focus on the pediatric CKD and ESRD populations. Finally, potential future directions of research are discussed.
KW - Anemia
KW - Cardiac disease
KW - Carnitine deficiency
KW - Children
KW - Kidney disease
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U2 - 10.1007/s00467-005-2085-4
DO - 10.1007/s00467-005-2085-4
M3 - Review article
C2 - 16374652
AN - SCOPUS:33244487237
SN - 0931-041X
VL - 21
SP - 308
EP - 317
JO - Pediatric Nephrology
JF - Pediatric Nephrology
IS - 3
ER -