TY - JOUR
T1 - The transition from radial glial to intermediate progenitor cell is inhibited by FGF signaling during corticogenesis
AU - Kang, Wenfei
AU - Wong, Li Chin
AU - Shi, Song Hai
AU - Hébert, Jean M.
PY - 2009/11/18
Y1 - 2009/11/18
N2 - During corticogenesis, the balance between the self-renewal of radial glial stem cells and the production of their descendent progenitor cells is essential in generating the correct size and cell composition of the neocortex. How the stem-to-progenitor cell transition is regulated is poorly understood. FGFs are commonly implicated in promoting proliferation of neural precursor cells, but it is unclear how they exert their effects on stem cells, progenitor cells, or both in vivo. Here, three FGF receptor genes are simultaneously deleted during cortical neurogenesis. In these mutants, radial glia are depleted due to an increased transition from an uncommitted state to a more differentiated one, initially causing an increase in progenitors, but ultimately resulting in a smaller cortex. The proliferation rate of progenitors themselves, however, is unchanged. These results indicate that FGFs normally repress the radial glia to progenitor cell transition during corticogenesis.
AB - During corticogenesis, the balance between the self-renewal of radial glial stem cells and the production of their descendent progenitor cells is essential in generating the correct size and cell composition of the neocortex. How the stem-to-progenitor cell transition is regulated is poorly understood. FGFs are commonly implicated in promoting proliferation of neural precursor cells, but it is unclear how they exert their effects on stem cells, progenitor cells, or both in vivo. Here, three FGF receptor genes are simultaneously deleted during cortical neurogenesis. In these mutants, radial glia are depleted due to an increased transition from an uncommitted state to a more differentiated one, initially causing an increase in progenitors, but ultimately resulting in a smaller cortex. The proliferation rate of progenitors themselves, however, is unchanged. These results indicate that FGFs normally repress the radial glia to progenitor cell transition during corticogenesis.
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U2 - 10.1523/JNEUROSCI.3844-09.2009
DO - 10.1523/JNEUROSCI.3844-09.2009
M3 - Article
C2 - 19923290
AN - SCOPUS:70949087224
SN - 0270-6474
VL - 29
SP - 14571
EP - 14580
JO - Journal of Neuroscience
JF - Journal of Neuroscience
IS - 46
ER -