The system epilepsies: A pathophysiological hypothesis

Giuliano Avanzini; Paolo Manganotti; Stefano Meletti; Solomon L. Moshé; Ferruccio Panzica; Peter Wolf; Giuseppe Capovilla

doi:10.1111/j.1528-1167.2012.03462.x

The system epilepsies: A pathophysiological hypothesis

Giuliano Avanzini, Paolo Manganotti, Stefano Meletti, Solomon L. Moshé, Ferruccio Panzica, Peter Wolf, Giuseppe Capovilla

Neurology

Research output: Contribution to journal › Review article › peer-review

138 Scopus citations

Abstract

We postulate that "system epilepsies" (SystE) are due to an enduring propensity to generate seizures of functionally characterized brain systems. Data supporting this hypothesis-that some types of epilepsy depend on the dysfunction of specific neural systems-are reviewed. The SystE hypothesis may drive pathophysiologic and clinical studies that can advance our understanding of epilepsies and can open up new therapeutic perspectives.

Original language	English (US)
Pages (from-to)	771-778
Number of pages	8
Journal	Epilepsia
Volume	53
Issue number	5
DOIs	https://doi.org/10.1111/j.1528-1167.2012.03462.x
State	Published - May 2012

Keywords

Cortico-cortical connections
Focal epilepsies
Generalized epilepsies
Neural systems
Thalamo-cortical systems

ASJC Scopus subject areas

Neurology
Clinical Neurology

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AU - Avanzini, Giuliano

AU - Manganotti, Paolo

AU - Meletti, Stefano

AU - Moshé, Solomon L.

AU - Panzica, Ferruccio

AU - Wolf, Peter

AU - Capovilla, Giuseppe

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AB - We postulate that "system epilepsies" (SystE) are due to an enduring propensity to generate seizures of functionally characterized brain systems. Data supporting this hypothesis-that some types of epilepsy depend on the dysfunction of specific neural systems-are reviewed. The SystE hypothesis may drive pathophysiologic and clinical studies that can advance our understanding of epilepsies and can open up new therapeutic perspectives.

KW - Cortico-cortical connections

KW - Focal epilepsies

KW - Generalized epilepsies

KW - Neural systems

KW - Thalamo-cortical systems

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The system epilepsies: A pathophysiological hypothesis

Abstract

Keywords

ASJC Scopus subject areas

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