The spectrum of onset of acute kidney injury in premature infants less than 30 weeks gestation

A. S. Weintraub, J. Connors, A. Carey, V. Blanco, R. S. Green

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


Objective : To determine risk factors for acute kidney injury (AKI) in preterm infants as a function of time of onset. Study Design : In this 5 1/2-year, single-center, retrospective study, incidence and timing of AKI was determined using modified Acute Kidney Injury Network criteria. Characteristics of newborns with and without AKI were compared by chi square and t-tests. Logistic regression was used to examine risk factors for AKI as a function of time of onset and potential confounders.Result:AKI occurred in 30.3% of 357 neonates; 72.2% was stage 1. Gestational ages (GA), initial Cr, maternal magnesium and volume resuscitation were associated with early AKI (days 0 to 1). Volume resuscitation, umbilical arterial line and receipt of non-steroidal anti-inflammatory drug (NSAID) for patent ductus arteriosus were associated with intermediate AKI (days 2 to 5). GA, steroids for early hypotension, necrotizing enterocolitis and sepsis were associated with late AKI (≥day 6). Conclusion : Stage 1 AKI is a common morbidity in our population. Risk factors for AKI in our population differed with time of onset.

Original languageEnglish (US)
Pages (from-to)474-480
Number of pages7
JournalJournal of Perinatology
Issue number6
StatePublished - Jun 1 2016
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology


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