Abstract
DNA damage and mutations have been implicated as key causal events in the biological process of aging. In this context, it has been hypothesized that the complex of genome maintenance systems acts as a longevity assurance system by signaling and repairing damage or removing cells that are beyond repair. In the past, various approaches have been taken to clarify the importance of preserving genome integrity for healthy aging. Here I will briefly review these approaches in the context of the progress made in improving our understanding of the interrelationship between DNA damage, genome maintenance and mutations.
Original language | English (US) |
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Pages (from-to) | 498-502 |
Number of pages | 5 |
Journal | Mechanisms of Ageing and Development |
Volume | 129 |
Issue number | 7-8 |
DOIs | |
State | Published - Jul 2008 |
Externally published | Yes |
Keywords
- Aging
- DNA damage
- Genome maintenance
- Life span
- Mutation
ASJC Scopus subject areas
- Aging
- Developmental Biology