The role of B cells and autoantibodies in neuropsychiatric lupus

Jing Wen; Ariel D. Stock; Samantha A. Chalmers; Chaim Putterman

doi:10.1016/j.autrev.2016.07.009

The role of B cells and autoantibodies in neuropsychiatric lupus

Jing Wen, Ariel D. Stock, Samantha A. Chalmers, Chaim Putterman

Medicine

Research output: Contribution to journal › Review article › peer-review

28 Scopus citations

Abstract

The central nervous system manifestations of SLE (neuropsychiatric lupus, NPSLE) occur frequently, though are often difficult to diagnose and treat. Symptoms of NPSLE can be quite diverse, including chronic cognitive and emotional manifestations, as well as acute presentations, such as stroke and seizures. Although the pathogenesis of NPSLE has yet to be well characterized, B-cell mediated damage is believed to be an important contributor. B-cells and autoantibodies may traverse the blood brain barrier promoting an inflammatory environment consisting of glia activation, neurodegeneration, and consequent averse behavioral outcomes. This review will evaluate the various suggested roles of B-cells and autoantibodies in NPSLE, as well as therapeutic modalities targeting these pathogenic mediators.

Original language	English (US)
Pages (from-to)	890-895
Number of pages	6
Journal	Autoimmunity Reviews
Volume	15
Issue number	9
DOIs	https://doi.org/10.1016/j.autrev.2016.07.009
State	Published - Sep 1 2016

Keywords

Autoantibodies
B cells
Neuropsychiatric lupus
SLE

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/j.autrev.2016.07.009

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title = "The role of B cells and autoantibodies in neuropsychiatric lupus",

abstract = "The central nervous system manifestations of SLE (neuropsychiatric lupus, NPSLE) occur frequently, though are often difficult to diagnose and treat. Symptoms of NPSLE can be quite diverse, including chronic cognitive and emotional manifestations, as well as acute presentations, such as stroke and seizures. Although the pathogenesis of NPSLE has yet to be well characterized, B-cell mediated damage is believed to be an important contributor. B-cells and autoantibodies may traverse the blood brain barrier promoting an inflammatory environment consisting of glia activation, neurodegeneration, and consequent averse behavioral outcomes. This review will evaluate the various suggested roles of B-cells and autoantibodies in NPSLE, as well as therapeutic modalities targeting these pathogenic mediators.",

keywords = "Autoantibodies, B cells, Neuropsychiatric lupus, SLE",

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AU - Stock, Ariel D.

AU - Chalmers, Samantha A.

AU - Putterman, Chaim

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N2 - The central nervous system manifestations of SLE (neuropsychiatric lupus, NPSLE) occur frequently, though are often difficult to diagnose and treat. Symptoms of NPSLE can be quite diverse, including chronic cognitive and emotional manifestations, as well as acute presentations, such as stroke and seizures. Although the pathogenesis of NPSLE has yet to be well characterized, B-cell mediated damage is believed to be an important contributor. B-cells and autoantibodies may traverse the blood brain barrier promoting an inflammatory environment consisting of glia activation, neurodegeneration, and consequent averse behavioral outcomes. This review will evaluate the various suggested roles of B-cells and autoantibodies in NPSLE, as well as therapeutic modalities targeting these pathogenic mediators.

AB - The central nervous system manifestations of SLE (neuropsychiatric lupus, NPSLE) occur frequently, though are often difficult to diagnose and treat. Symptoms of NPSLE can be quite diverse, including chronic cognitive and emotional manifestations, as well as acute presentations, such as stroke and seizures. Although the pathogenesis of NPSLE has yet to be well characterized, B-cell mediated damage is believed to be an important contributor. B-cells and autoantibodies may traverse the blood brain barrier promoting an inflammatory environment consisting of glia activation, neurodegeneration, and consequent averse behavioral outcomes. This review will evaluate the various suggested roles of B-cells and autoantibodies in NPSLE, as well as therapeutic modalities targeting these pathogenic mediators.

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The role of B cells and autoantibodies in neuropsychiatric lupus

Abstract

Keywords

ASJC Scopus subject areas

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