TY - JOUR
T1 - The role of B cells and autoantibodies in neuropsychiatric lupus
AU - Wen, Jing
AU - Stock, Ariel D.
AU - Chalmers, Samantha A.
AU - Putterman, Chaim
N1 - Funding Information:
These studies were supported by a research grant from the NIH ( AR065594 ) to C. Putterman.
Publisher Copyright:
© 2016 Elsevier B.V.
PY - 2016/9/1
Y1 - 2016/9/1
N2 - The central nervous system manifestations of SLE (neuropsychiatric lupus, NPSLE) occur frequently, though are often difficult to diagnose and treat. Symptoms of NPSLE can be quite diverse, including chronic cognitive and emotional manifestations, as well as acute presentations, such as stroke and seizures. Although the pathogenesis of NPSLE has yet to be well characterized, B-cell mediated damage is believed to be an important contributor. B-cells and autoantibodies may traverse the blood brain barrier promoting an inflammatory environment consisting of glia activation, neurodegeneration, and consequent averse behavioral outcomes. This review will evaluate the various suggested roles of B-cells and autoantibodies in NPSLE, as well as therapeutic modalities targeting these pathogenic mediators.
AB - The central nervous system manifestations of SLE (neuropsychiatric lupus, NPSLE) occur frequently, though are often difficult to diagnose and treat. Symptoms of NPSLE can be quite diverse, including chronic cognitive and emotional manifestations, as well as acute presentations, such as stroke and seizures. Although the pathogenesis of NPSLE has yet to be well characterized, B-cell mediated damage is believed to be an important contributor. B-cells and autoantibodies may traverse the blood brain barrier promoting an inflammatory environment consisting of glia activation, neurodegeneration, and consequent averse behavioral outcomes. This review will evaluate the various suggested roles of B-cells and autoantibodies in NPSLE, as well as therapeutic modalities targeting these pathogenic mediators.
KW - Autoantibodies
KW - B cells
KW - Neuropsychiatric lupus
KW - SLE
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U2 - 10.1016/j.autrev.2016.07.009
DO - 10.1016/j.autrev.2016.07.009
M3 - Review article
C2 - 27389531
AN - SCOPUS:84979500276
SN - 1568-9972
VL - 15
SP - 890
EP - 895
JO - Autoimmunity Reviews
JF - Autoimmunity Reviews
IS - 9
ER -