The role of aquaporin 4 in brain tumors: implications for pathophysiology, diagnosis and therapy

Mohammad Behnam; Alireza Motamedzadeh; Marzieh Aalinezhad; Ehsan Dadgostar; Fatemeh Zahra Rashidi Noshabad; Mohammad Pourfridoni; Maedeh Raei; Hamed Mirzaei; Michael Aschner; Omid Reza Tamtaji

doi:10.1007/s11033-022-07656-y

The role of aquaporin 4 in brain tumors: implications for pathophysiology, diagnosis and therapy

Mohammad Behnam
, Alireza Motamedzadeh
, Marzieh Aalinezhad
, Ehsan Dadgostar
, Fatemeh Zahra Rashidi Noshabad
, Mohammad Pourfridoni
, Maedeh Raei
, Hamed Mirzaei
, Michael Aschner
, Omid Reza Tamtaji

Molecular Pharmacology

Research output: Contribution to journal › Review article › peer-review

16 Scopus citations

Abstract

Primary brain tumors are a heterogeneous group of tumors that arise from cells intrinsic to the central nervous system (CNS). Aquaporin-4 (AQP4) has been implicated in the pathogenesis of brain tumors. Previous reports have documented a relationship between AQP4 and several molecular pathways associated with the etiology of brain tumors, such as apoptosis, invasion and cell migration. AQP4 affects apoptosis via cytochrome C, Bad and Bcl-2, as well as invasion and migration via IDO1/TDO–Kyn–AhR axis, lncRNA LINC00461, miR-216a, miRNA-320a and MMPs. In addition, inhibition of AQP4 mitigates the progression of brain tumors. This review summarizes current knowledge and evidence regarding the relationship between AQP4 and brain tumors, and the mechanisms involved.

Original language	English (US)
Pages (from-to)	10609-10615
Number of pages	7
Journal	Molecular Biology Reports
Volume	49
Issue number	11
DOIs	https://doi.org/10.1007/s11033-022-07656-y
State	Published - Nov 2022

Keywords

Aquaporin 4
Astrocytoma
Glioblastoma
Glioma
Meningioma

ASJC Scopus subject areas

Molecular Biology
Genetics

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10.1007/s11033-022-07656-y

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title = "The role of aquaporin 4 in brain tumors: implications for pathophysiology, diagnosis and therapy",

abstract = "Primary brain tumors are a heterogeneous group of tumors that arise from cells intrinsic to the central nervous system (CNS). Aquaporin-4 (AQP4) has been implicated in the pathogenesis of brain tumors. Previous reports have documented a relationship between AQP4 and several molecular pathways associated with the etiology of brain tumors, such as apoptosis, invasion and cell migration. AQP4 affects apoptosis via cytochrome C, Bad and Bcl-2, as well as invasion and migration via IDO1/TDO–Kyn–AhR axis, lncRNA LINC00461, miR-216a, miRNA-320a and MMPs. In addition, inhibition of AQP4 mitigates the progression of brain tumors. This review summarizes current knowledge and evidence regarding the relationship between AQP4 and brain tumors, and the mechanisms involved.",

keywords = "Aquaporin 4, Astrocytoma, Glioblastoma, Glioma, Meningioma",

author = "Mohammad Behnam and Alireza Motamedzadeh and Marzieh Aalinezhad and Ehsan Dadgostar and \{Rashidi Noshabad\}, \{Fatemeh Zahra\} and Mohammad Pourfridoni and Maedeh Raei and Hamed Mirzaei and Michael Aschner and Tamtaji, \{Omid Reza\}",

note = "Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive licence to Springer Nature B.V.",

year = "2022",

month = nov,

doi = "10.1007/s11033-022-07656-y",

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AU - Behnam, Mohammad

AU - Motamedzadeh, Alireza

AU - Aalinezhad, Marzieh

AU - Dadgostar, Ehsan

AU - Rashidi Noshabad, Fatemeh Zahra

AU - Pourfridoni, Mohammad

AU - Raei, Maedeh

AU - Mirzaei, Hamed

AU - Aschner, Michael

AU - Tamtaji, Omid Reza

PY - 2022/11

Y1 - 2022/11

N2 - Primary brain tumors are a heterogeneous group of tumors that arise from cells intrinsic to the central nervous system (CNS). Aquaporin-4 (AQP4) has been implicated in the pathogenesis of brain tumors. Previous reports have documented a relationship between AQP4 and several molecular pathways associated with the etiology of brain tumors, such as apoptosis, invasion and cell migration. AQP4 affects apoptosis via cytochrome C, Bad and Bcl-2, as well as invasion and migration via IDO1/TDO–Kyn–AhR axis, lncRNA LINC00461, miR-216a, miRNA-320a and MMPs. In addition, inhibition of AQP4 mitigates the progression of brain tumors. This review summarizes current knowledge and evidence regarding the relationship between AQP4 and brain tumors, and the mechanisms involved.

AB - Primary brain tumors are a heterogeneous group of tumors that arise from cells intrinsic to the central nervous system (CNS). Aquaporin-4 (AQP4) has been implicated in the pathogenesis of brain tumors. Previous reports have documented a relationship between AQP4 and several molecular pathways associated with the etiology of brain tumors, such as apoptosis, invasion and cell migration. AQP4 affects apoptosis via cytochrome C, Bad and Bcl-2, as well as invasion and migration via IDO1/TDO–Kyn–AhR axis, lncRNA LINC00461, miR-216a, miRNA-320a and MMPs. In addition, inhibition of AQP4 mitigates the progression of brain tumors. This review summarizes current knowledge and evidence regarding the relationship between AQP4 and brain tumors, and the mechanisms involved.

KW - Aquaporin 4

KW - Astrocytoma

KW - Glioblastoma

KW - Glioma

KW - Meningioma

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UR - https://www.scopus.com/pages/publications/85132137830#tab=citedBy

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DO - 10.1007/s11033-022-07656-y

M3 - Review article

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SN - 0301-4851

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JO - Molecular Biology Reports

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IS - 11

ER -

The role of aquaporin 4 in brain tumors: implications for pathophysiology, diagnosis and therapy

Abstract

Keywords

ASJC Scopus subject areas

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