The relationship between hippocampal volume, chronic pain, and depressive symptoms in older adults

Ali Ezzati; Andrea R. Zammit; Michael L. Lipton; Richard B. Lipton

doi:10.1016/j.pscychresns.2019.05.003

The relationship between hippocampal volume, chronic pain, and depressive symptoms in older adults

Ali Ezzati, Andrea R. Zammit, Michael L. Lipton, Richard B. Lipton

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

We aimed to test the hypothesis that the effect of chronic pain on depressive symptoms is mediated through hippocampal volume (HV). Participants were 131 non-demented adults over the age of 70 years from the Einstein Aging Study. Smaller right and left HV were both associated with higher depressive symptoms, but only smaller right HV was associated with chronic pain. In mediation models, right HV was a significant mediator for the effect of chronic pain on depression. Our findings suggest presence of a shared brain substrates between chronic pain and depression as reflected by right HV.

Original language	English (US)
Pages (from-to)	10-12
Number of pages	3
Journal	Psychiatry Research - Neuroimaging
Volume	289
DOIs	https://doi.org/10.1016/j.pscychresns.2019.05.003
State	Published - Jul 30 2019

Keywords

Chronic pain
Depressive symptoms
Hippocampal volume

ASJC Scopus subject areas

Neuroscience (miscellaneous)
Radiology Nuclear Medicine and imaging
Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.pscychresns.2019.05.003

Cite this

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title = "The relationship between hippocampal volume, chronic pain, and depressive symptoms in older adults",

abstract = "We aimed to test the hypothesis that the effect of chronic pain on depressive symptoms is mediated through hippocampal volume (HV). Participants were 131 non-demented adults over the age of 70 years from the Einstein Aging Study. Smaller right and left HV were both associated with higher depressive symptoms, but only smaller right HV was associated with chronic pain. In mediation models, right HV was a significant mediator for the effect of chronic pain on depression. Our findings suggest presence of a shared brain substrates between chronic pain and depression as reflected by right HV.",

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AU - Ezzati, Ali

AU - Zammit, Andrea R.

AU - Lipton, Michael L.

AU - Lipton, Richard B.

PY - 2019/7/30

Y1 - 2019/7/30

N2 - We aimed to test the hypothesis that the effect of chronic pain on depressive symptoms is mediated through hippocampal volume (HV). Participants were 131 non-demented adults over the age of 70 years from the Einstein Aging Study. Smaller right and left HV were both associated with higher depressive symptoms, but only smaller right HV was associated with chronic pain. In mediation models, right HV was a significant mediator for the effect of chronic pain on depression. Our findings suggest presence of a shared brain substrates between chronic pain and depression as reflected by right HV.

AB - We aimed to test the hypothesis that the effect of chronic pain on depressive symptoms is mediated through hippocampal volume (HV). Participants were 131 non-demented adults over the age of 70 years from the Einstein Aging Study. Smaller right and left HV were both associated with higher depressive symptoms, but only smaller right HV was associated with chronic pain. In mediation models, right HV was a significant mediator for the effect of chronic pain on depression. Our findings suggest presence of a shared brain substrates between chronic pain and depression as reflected by right HV.

KW - Chronic pain

KW - Depressive symptoms

KW - Hippocampal volume

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The relationship between hippocampal volume, chronic pain, and depressive symptoms in older adults

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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