The potential of ovarian tissue transplant to preserve fertility

Kutluk Oktay, Erkan Buyuk

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations


Laboratory research on ovarian cryopreservation and transplantation began in the 1950s leading to clinical studies in the 2000s. The research that was performed during this half a century indicated that cryopreserved ovarian tissue has the potential to restore fertility in women who face premature ovarian failure due to chemotherapy, radiotherapy or surgery. Until today, ovarian function has been restored in at least four women. Even though no pregnancies have been reported to date from these clinical studies, animal studies indicate that this is a valid prospect for humans. Future clinical trials will determine in a larger number of patients the longevity of ovarian grafts, normalcy of hormone production and ovarian follicle development, possibility and safety of pregnancy and the safety of auto-transplantation in cancer patients. In addition, further basic research may be needed to develop better cryoprotectants and cryopreservation techniques. However, the major improvement in the efficiency of ovarian transplantation is anticipated to come from research exploring the revascularization process.

Original languageEnglish (US)
Pages (from-to)361-370
Number of pages10
JournalExpert opinion on biological therapy
Issue number4
StatePublished - 2002
Externally publishedYes


  • Cryopreservation
  • Fertility preservation
  • Ovarian transplantation
  • Ovary

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry


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