TY - JOUR
T1 - The influences of ambient fine particulate matter constituents on plasma hormones, circulating TMAO levels and blood pressure
T2 - A panel study in China
AU - Wang, Jiajia
AU - Wu, Shenshen
AU - Cui, Jian
AU - Ding, Zhen
AU - Meng, Qingtao
AU - Sun, Hao
AU - Li, Bin
AU - Teng, Jun
AU - Dong, Yanping
AU - Aschner, Michael
AU - Wu, Shaowei
AU - Li, Xiaobo
AU - Chen, Rui
N1 - Funding Information:
This work was financially supported by the National Science Fund for Distinguished Young Scholars ( 82025031 ), the State Key Program of the National Natural Science Foundation of China ( 81730088 ), and the National Natural Science Foundation of China ( 81973084 , 82003498 , 82003499 , and 91943301 ). Guangdong Provincial Natural Science Foundation Team Project ( 2018B030312005 ). MA was supported by National Institute of Environmental Health Sciences (NIEHS) ( R01 ES10563 , R01 ES07331 , and R01 ES020852 ).
Publisher Copyright:
© 2021
PY - 2022/3/1
Y1 - 2022/3/1
N2 - Considerable investigations have been carried out to address the relationship between ambient fine particulate matter (PM2.5) and blood pressure (BP) in patients with hypertension. However, few studies have explored the influence of PM2.5 and its constituents on Trimethylamine N-oxide (TMAO), an established risk factor for hypertension and cardiovascular disease (CVD), particularly in severely air-polluted areas. To explore the potential impact of PM2.5 constituents on BP, plasma hormones, and TMAO, a panel study was conducted to investigate changes in BP, plasma hormones, and TMAO in response to ambient air pollution exposure in stage 1 hypertensive young adults. Linear mixed effect models were used to estimate the cumulative effects of fine particulate matters (PM2.5) and its constituents on BP, plasma hormones and TMAO. We found that one interquartile range (IQR) (35 μg/m3) increase in 0–1 day moving-average PM2.5 concentrations was statistically significantly associated with elevated systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) with estimated values of 0.13 (95% confidence interval (CI): 0.03 to 0.23) mmHg, 0.18 (95% CI: 0.08 to 0.28) mmHg, and 0.17 (95% CI: 0.09 to 0.26) mmHg, respectively. Hormone disturbance in the renin-angiotensin-aldosterone system was also associated with PM2.5 exposure. Elevated TMAO levels with an IQR increase for 0–4, 0–5, 0–6 moving-average concentrations of PM2.5 were found, and the increased values ranged from 26.28 (95% CI: 2.92 to 49.64) to 60.78 (31.95–89.61) ng/ml. More importantly, the PM2.5-bound metal constituents, such as manganese (Mn), titanium (Ti), and selenium (Se) showed robust associations with elevated BP and plasma TMAO levels. This study demonstrates associations between PM2.5 metal constituents and increased BP, changes in plasma hormones and TMAO, in stage 1 hypertensive young adults. Source control, aiming to reduce the emission of PM2.5-bound metals should be implemented to reduce the risk of hypertension and CVD.
AB - Considerable investigations have been carried out to address the relationship between ambient fine particulate matter (PM2.5) and blood pressure (BP) in patients with hypertension. However, few studies have explored the influence of PM2.5 and its constituents on Trimethylamine N-oxide (TMAO), an established risk factor for hypertension and cardiovascular disease (CVD), particularly in severely air-polluted areas. To explore the potential impact of PM2.5 constituents on BP, plasma hormones, and TMAO, a panel study was conducted to investigate changes in BP, plasma hormones, and TMAO in response to ambient air pollution exposure in stage 1 hypertensive young adults. Linear mixed effect models were used to estimate the cumulative effects of fine particulate matters (PM2.5) and its constituents on BP, plasma hormones and TMAO. We found that one interquartile range (IQR) (35 μg/m3) increase in 0–1 day moving-average PM2.5 concentrations was statistically significantly associated with elevated systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) with estimated values of 0.13 (95% confidence interval (CI): 0.03 to 0.23) mmHg, 0.18 (95% CI: 0.08 to 0.28) mmHg, and 0.17 (95% CI: 0.09 to 0.26) mmHg, respectively. Hormone disturbance in the renin-angiotensin-aldosterone system was also associated with PM2.5 exposure. Elevated TMAO levels with an IQR increase for 0–4, 0–5, 0–6 moving-average concentrations of PM2.5 were found, and the increased values ranged from 26.28 (95% CI: 2.92 to 49.64) to 60.78 (31.95–89.61) ng/ml. More importantly, the PM2.5-bound metal constituents, such as manganese (Mn), titanium (Ti), and selenium (Se) showed robust associations with elevated BP and plasma TMAO levels. This study demonstrates associations between PM2.5 metal constituents and increased BP, changes in plasma hormones and TMAO, in stage 1 hypertensive young adults. Source control, aiming to reduce the emission of PM2.5-bound metals should be implemented to reduce the risk of hypertension and CVD.
KW - Ambient PM
KW - Blood pressure
KW - Constituents
KW - Panel study
KW - Trimethylamine N-oxide (TMAO)
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U2 - 10.1016/j.envpol.2021.118746
DO - 10.1016/j.envpol.2021.118746
M3 - Article
C2 - 34968616
AN - SCOPUS:85121855467
SN - 0269-7491
VL - 296
JO - Environmental Pollution
JF - Environmental Pollution
M1 - 118746
ER -
