The impact of manganese on neurotransmitter systems

Ana Thalita Gonçalves Soares, Aline de Castro Silva, Alexey A. Tinkov, Haroon Khan, Abel Santamaría, Margarita G. Skalnaya, Anatoly V. Skalny, Aristidis Tsatsakis, Aaron B. Bowman, Michael Aschner, Daiana Silva Ávila

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations


Background: Manganese (Mn) is a metal ubiquitously present in nature and essential for many living organisms. As a trace element, it is required in small amounts for the proper functioning of several important enzymes, and reports of Mn deficiency are indeed rare. Methods: This mini-review will cover aspects of Mn toxicokinetics and its impact on brain neurotransmission, as well as its Janus-faced effects on humans and other animal's health. Results: The estimated safe upper limit of intracellular Mn for physiological function is in anarrow range of 20–53 μM.Therefore, intake of higher levels of Mn and the outcomes, especially to the nervous system, have been well documented. Conclusion: The metal affects mostly the brain by accumulating in specific areas, altering cognitive functions and locomotion, thus severely impacting the health of the exposed organisms.

Original languageEnglish (US)
Article number126554
JournalJournal of Trace Elements in Medicine and Biology
StatePublished - Sep 2020


  • Manganese
  • Manganism
  • Neurotoxicity
  • Trace elements

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Inorganic Chemistry


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