The immunoglobulin E-allergen interaction: A target for therapy of type I allergic diseases

Rudolf Valenta; Steven Almo; Tanja Ball; Christiane Dolecek; Peter Steinberger; Sylvia Laffer; Petra Eibensteiner; Sabine Flicker; Susanne Vrtala; Susanne Spitzauer; Peter Valent; Stephan Denepoux; Dietrich Kraft; Jacques Banchereau; Serge Lebecque

doi:10.1159/000023942

The immunoglobulin E-allergen interaction: A target for therapy of type I allergic diseases

Rudolf Valenta, Steven Almo, Tanja Ball, Christiane Dolecek, Peter Steinberger, Sylvia Laffer, Petra Eibensteiner, Sabine Flicker, Susanne Vrtala, Susanne Spitzauer, Peter Valent, Stephan Denepoux, Dietrich Kraft, Jacques Banchereau, Serge Lebecque

Biochemistry

Research output: Contribution to journal › Review article › peer-review

30 Scopus citations

Abstract

The interaction of immunoglobulin E and otherwise harmless antigens (allergens) leads in sensitized individuals through effector cell activation to the immediate induction of a cascade of inflammatory reactions, the hallmark of type I allergy. Recently, the molecular and structural characterization of allergens, specific IgE antibodies and their epitopes has made rapid progress. Here we discuss active and passive strategies for therapy of type I allergy, which are based on interfering with the IgE-allergen interaction.

Original language	English (US)
Pages (from-to)	167-176
Number of pages	10
Journal	International Archives of Allergy and Immunology
Volume	116
Issue number	3
DOIs	https://doi.org/10.1159/000023942
State	Published - Jul 1998

Keywords

Blocking antibody
Immunoglobulin E
Immunotherapy
Recombinant allergens
Type I allergy

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1159/000023942

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Valenta, R., Almo, S., Ball, T., Dolecek, C., Steinberger, P., Laffer, S., Eibensteiner, P., Flicker, S., Vrtala, S., Spitzauer, S., Valent, P., Denepoux, S., Kraft, D., Banchereau, J., & Lebecque, S. (1998). The immunoglobulin E-allergen interaction: A target for therapy of type I allergic diseases. International Archives of Allergy and Immunology, 116(3), 167-176. https://doi.org/10.1159/000023942

Valenta, R, Almo, S, Ball, T, Dolecek, C, Steinberger, P, Laffer, S, Eibensteiner, P, Flicker, S, Vrtala, S, Spitzauer, S, Valent, P, Denepoux, S, Kraft, D, Banchereau, J & Lebecque, S 1998, 'The immunoglobulin E-allergen interaction: A target for therapy of type I allergic diseases', International Archives of Allergy and Immunology, vol. 116, no. 3, pp. 167-176. https://doi.org/10.1159/000023942

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abstract = "The interaction of immunoglobulin E and otherwise harmless antigens (allergens) leads in sensitized individuals through effector cell activation to the immediate induction of a cascade of inflammatory reactions, the hallmark of type I allergy. Recently, the molecular and structural characterization of allergens, specific IgE antibodies and their epitopes has made rapid progress. Here we discuss active and passive strategies for therapy of type I allergy, which are based on interfering with the IgE-allergen interaction.",

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AU - Valenta, Rudolf

AU - Almo, Steven

AU - Ball, Tanja

AU - Dolecek, Christiane

AU - Steinberger, Peter

AU - Laffer, Sylvia

AU - Eibensteiner, Petra

AU - Flicker, Sabine

AU - Vrtala, Susanne

AU - Spitzauer, Susanne

AU - Valent, Peter

AU - Denepoux, Stephan

AU - Kraft, Dietrich

AU - Banchereau, Jacques

AU - Lebecque, Serge

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AB - The interaction of immunoglobulin E and otherwise harmless antigens (allergens) leads in sensitized individuals through effector cell activation to the immediate induction of a cascade of inflammatory reactions, the hallmark of type I allergy. Recently, the molecular and structural characterization of allergens, specific IgE antibodies and their epitopes has made rapid progress. Here we discuss active and passive strategies for therapy of type I allergy, which are based on interfering with the IgE-allergen interaction.

KW - Blocking antibody

KW - Immunoglobulin E

KW - Immunotherapy

KW - Recombinant allergens

KW - Type I allergy

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The immunoglobulin E-allergen interaction: A target for therapy of type I allergic diseases

Abstract

Keywords

ASJC Scopus subject areas

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