The gut microbiome and microbial metabolites in acute myocardial infarction

Chenglin Liu, Zhonghan Sun, Shalaimaiti Shali, Zhendong Mei, Shufu Chang, Hanjun Mo, Lili Xu, Yanni Pu, Huihui Guan, Guo Chong Chen, Qibin Qi, Zhexue Quan, Ji Qi, Kang Yao, Yuxiang Dai, Yan Zheng, Junbo Ge

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Emerging evidence has highlighted the role of gut microbiome in human health. However, the integrative role of gut microbiome and microbial metabolites in acute myocardial infarction (AMI) remains unclear. The current study profiles the microbial community through 16S rRNA gene sequencing and shotgun metagenomic sequencing and measures fecal short-chain fatty acids and circulating choline pathway metabolites among 117 new-onset AMI cases and 78 controls. Significant microbial alternations are observed in AMI patients compared with controls (P = 0.001). The abundances of nine species (e.g., Streptococcus salivarius and Klebsiella pneumoniae) are positively associated, and one species (Roseburia hominis) is inversely associated with AMI status and severity. A gut microbial score at disease onset is associated with the risk of major adverse cardiovascular events in 3.2 years (hazard ratio [95% CI]: 2.01 [1.04–4.24]) in AMI patients. The molar proportions of fecal acetate and butyrate are higher, and the circulating levels of choline and carnitine are lower in AMI patients than in controls. In addition, disease classifiers show that AMI cases and controls have a more distinct pattern in taxonomical composition than in pathways or metabolites. Our findings suggest that microbial composition and functional potentials are associated with AMI status and severity.

Original languageEnglish (US)
Pages (from-to)569-578
Number of pages10
JournalJournal of Genetics and Genomics
Issue number6
StatePublished - Jun 2022


  • Acute myocardial infarction
  • Atherosclerosis
  • Microbiome
  • Short-chain fatty acids

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics


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