The G protein connection: molecular basis of membrane association

Allen M. Spiegel; Peter S. Backlund; James E. Butrynski; Teresa L.Z. Jones; William F. Simonds

doi:10.1016/0968-0004(91)90139-M

The G protein connection: molecular basis of membrane association

Allen M. Spiegel
, Peter S. Backlund
, James E. Butrynski
, Teresa L.Z. Jones
, William F. Simonds

Research output: Contribution to journal › Article › peer-review

103 Scopus citations

Abstract

Two distinct types of lipid modification, myristoylation and isoprenylation, are critical for membrane association of heterotrimeric G proteins. Elucidation of the molecular basis for G protein membrane association has important implications for understanding G protein structure and function, and is relevant to potential therapeutic approaches to AIDS and cancer.

Original language	English (US)
Pages (from-to)	338-341
Number of pages	4
Journal	Trends in Biochemical Sciences
Volume	16
Issue number	C
DOIs	https://doi.org/10.1016/0968-0004(91)90139-M
State	Published - 1991
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Biochemistry
Molecular Biology

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10.1016/0968-0004(91)90139-M

Cite this

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title = "The G protein connection: molecular basis of membrane association",

abstract = "Two distinct types of lipid modification, myristoylation and isoprenylation, are critical for membrane association of heterotrimeric G proteins. Elucidation of the molecular basis for G protein membrane association has important implications for understanding G protein structure and function, and is relevant to potential therapeutic approaches to AIDS and cancer.",

author = "Spiegel, \{Allen M.\} and Backlund, \{Peter S.\} and Butrynski, \{James E.\} and Jones, \{Teresa L.Z.\} and Simonds, \{William F.\}",

year = "1991",

doi = "10.1016/0968-0004(91)90139-M",

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journal = "Trends in Biochemical Sciences",

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T2 - molecular basis of membrane association

AU - Spiegel, Allen M.

AU - Backlund, Peter S.

AU - Butrynski, James E.

AU - Jones, Teresa L.Z.

AU - Simonds, William F.

PY - 1991

Y1 - 1991

N2 - Two distinct types of lipid modification, myristoylation and isoprenylation, are critical for membrane association of heterotrimeric G proteins. Elucidation of the molecular basis for G protein membrane association has important implications for understanding G protein structure and function, and is relevant to potential therapeutic approaches to AIDS and cancer.

AB - Two distinct types of lipid modification, myristoylation and isoprenylation, are critical for membrane association of heterotrimeric G proteins. Elucidation of the molecular basis for G protein membrane association has important implications for understanding G protein structure and function, and is relevant to potential therapeutic approaches to AIDS and cancer.

UR - https://www.scopus.com/pages/publications/0025740984

UR - https://www.scopus.com/pages/publications/0025740984#tab=citedBy

U2 - 10.1016/0968-0004(91)90139-M

DO - 10.1016/0968-0004(91)90139-M

M3 - Article

C2 - 1949155

AN - SCOPUS:0025740984

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EP - 341

JO - Trends in Biochemical Sciences

JF - Trends in Biochemical Sciences

IS - C

ER -

The G protein connection: molecular basis of membrane association

Abstract

UN SDGs

ASJC Scopus subject areas

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