Abstract
The uncoating process of HIV-1 is a poorly understood process, so the development of a reliable assay to study uncoating is critical for moving the field forward. Here we describe an uncoating assay that currently represents the state-of-the-art biochemical procedure for monitoring uncoating and core stability during infection. This assay is based on the biochemical separation of soluble capsid protein from particulate capsid cores and provides information about the fate of the capsid during infection.
| Original language | English (US) |
|---|---|
| Title of host publication | Human Retroviruses |
| Subtitle of host publication | Methods and Protocols |
| Publisher | Humana Press Inc. |
| Pages | 29-36 |
| Number of pages | 8 |
| ISBN (Print) | 9781627036696 |
| DOIs | |
| State | Published - 2014 |
Publication series
| Name | Methods in Molecular Biology |
|---|---|
| Volume | 1087 |
| ISSN (Print) | 1064-3745 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Capsid
- HIV-1 core
- Sucrose cushion
- TRIM5α
- Uncoating
ASJC Scopus subject areas
- Molecular Biology
- Genetics
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