The ets protein PEA3 suppresses HER-2/neu overexpression and inhibits tumorigenesis

Xiangming Xing; Shao Chun Wang; Weiya Xia; Yiyu Zou; Ruping Shao; Ka Yin Kwong; Zhenming Yu; Su Zhang; Susan Miller; Leaf Huang; Mien Chie Hung

doi:10.1038/72294

The ets protein PEA3 suppresses HER-2/neu overexpression and inhibits tumorigenesis

Xiangming Xing, Shao Chun Wang, Weiya Xia, Yiyu Zou, Ruping Shao, Ka Yin Kwong, Zhenming Yu, Su Zhang, Susan Miller, Leaf Huang, Mien Chie Hung

Research output: Contribution to journal › Article › peer-review

161 Scopus citations

Abstract

Because HER-2/neu overexpression is important in cancer development, we looked for a method of suppressing the cell transformation mediated by HER- 2/neu overexpression. We have identified that the DNA-binding protein PEA3, which is encoded by a previously isolated gene of the ets family, specifically targeted a DNA sequence on the HER-2/neu promoter and downregulated the promoter activity. Expression of PEA3 resulted in preferential inhibition of cell growth and tumor development of HER-2/neu- overexpressing cancer cells. This is a new approach to targeting HER-2/neu overexpression and also provides a rationale to the design for repressors of diseases caused by overexpression of pathogenic genes.

Original language	English (US)
Pages (from-to)	189-195
Number of pages	7
Journal	Nature Medicine
Volume	6
Issue number	2
DOIs	https://doi.org/10.1038/72294
State	Published - Feb 2000
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/72294

Cite this

@article{cc6ddf8a8afe4a60a5de1fa27939fa29,

title = "The ets protein PEA3 suppresses HER-2/neu overexpression and inhibits tumorigenesis",

abstract = "Because HER-2/neu overexpression is important in cancer development, we looked for a method of suppressing the cell transformation mediated by HER- 2/neu overexpression. We have identified that the DNA-binding protein PEA3, which is encoded by a previously isolated gene of the ets family, specifically targeted a DNA sequence on the HER-2/neu promoter and downregulated the promoter activity. Expression of PEA3 resulted in preferential inhibition of cell growth and tumor development of HER-2/neu- overexpressing cancer cells. This is a new approach to targeting HER-2/neu overexpression and also provides a rationale to the design for repressors of diseases caused by overexpression of pathogenic genes.",

author = "Xiangming Xing and Wang, {Shao Chun} and Weiya Xia and Yiyu Zou and Ruping Shao and Kwong, {Ka Yin} and Zhenming Yu and Su Zhang and Susan Miller and Leaf Huang and Hung, {Mien Chie}",

note = "Funding Information: Acknowledgments The authors thank J. H. Chen for providing PEA3 cDNA. This work was partially supported by National Institute of Health (NIH) grants (to M.-C. H. and L.H.), M. D. Anderson Breast Cancer Research Program, as well as a NIH cancer center core grant and Biocyte Therapeutics, Inc.. X.X. is the recipient of a predoctoral fellowship from the Breast Cancer Research Program of the Department of Defense, and Z.Y. is a predoctoral fellow under the US Army Breast Cancer Research Training Grant.",

year = "2000",

month = feb,

doi = "10.1038/72294",

language = "English (US)",

volume = "6",

pages = "189--195",

journal = "Nature Medicine",

issn = "1078-8956",

publisher = "Nature Publishing Group",

number = "2",

}

TY - JOUR

T1 - The ets protein PEA3 suppresses HER-2/neu overexpression and inhibits tumorigenesis

AU - Xing, Xiangming

AU - Wang, Shao Chun

AU - Xia, Weiya

AU - Zou, Yiyu

AU - Shao, Ruping

AU - Kwong, Ka Yin

AU - Yu, Zhenming

AU - Zhang, Su

AU - Miller, Susan

AU - Huang, Leaf

AU - Hung, Mien Chie

N1 - Funding Information: Acknowledgments The authors thank J. H. Chen for providing PEA3 cDNA. This work was partially supported by National Institute of Health (NIH) grants (to M.-C. H. and L.H.), M. D. Anderson Breast Cancer Research Program, as well as a NIH cancer center core grant and Biocyte Therapeutics, Inc.. X.X. is the recipient of a predoctoral fellowship from the Breast Cancer Research Program of the Department of Defense, and Z.Y. is a predoctoral fellow under the US Army Breast Cancer Research Training Grant.

PY - 2000/2

Y1 - 2000/2

N2 - Because HER-2/neu overexpression is important in cancer development, we looked for a method of suppressing the cell transformation mediated by HER- 2/neu overexpression. We have identified that the DNA-binding protein PEA3, which is encoded by a previously isolated gene of the ets family, specifically targeted a DNA sequence on the HER-2/neu promoter and downregulated the promoter activity. Expression of PEA3 resulted in preferential inhibition of cell growth and tumor development of HER-2/neu- overexpressing cancer cells. This is a new approach to targeting HER-2/neu overexpression and also provides a rationale to the design for repressors of diseases caused by overexpression of pathogenic genes.

AB - Because HER-2/neu overexpression is important in cancer development, we looked for a method of suppressing the cell transformation mediated by HER- 2/neu overexpression. We have identified that the DNA-binding protein PEA3, which is encoded by a previously isolated gene of the ets family, specifically targeted a DNA sequence on the HER-2/neu promoter and downregulated the promoter activity. Expression of PEA3 resulted in preferential inhibition of cell growth and tumor development of HER-2/neu- overexpressing cancer cells. This is a new approach to targeting HER-2/neu overexpression and also provides a rationale to the design for repressors of diseases caused by overexpression of pathogenic genes.

UR - http://www.scopus.com/inward/record.url?scp=17444448391&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=17444448391&partnerID=8YFLogxK

U2 - 10.1038/72294

DO - 10.1038/72294

M3 - Article

C2 - 10655108

AN - SCOPUS:17444448391

SN - 1078-8956

VL - 6

SP - 189

EP - 195

JO - Nature Medicine

JF - Nature Medicine

IS - 2

ER -

The ets protein PEA3 suppresses HER-2/neu overexpression and inhibits tumorigenesis

Abstract

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this